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Table of Contents
Vol. 57, No. 4, 2007
Issue release date: May 2007
Section title: Original Paper
Eur Neurol 2007;57:212–218
(DOI:10.1159/000099161)

Causes of Ischemic Stroke in Young Adults, and Evolution of the Etiological Diagnosis over the Long Term

Varona J.F.a · Guerra J.M.a · Bermejo F.b · Molina J.A.b · Gomez de la Cámara A.c
Departments of aInternal Medicine, and bNeurology, and cEpidemiology Investigation Unit, University Hospital ‘12 de Octubre’, Madrid, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 04, 2006
Accepted: November 26, 2006
Published online: January 31, 2007
Issue release date: May 2007

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background: Causes of ischemic stroke in young adults (15–45 years) are diverse, but undetermined etiology is common in a majority of studies. Aims: The present series study aims to evaluate causes and changes in the etiological diagnosis of ischemic stroke in young adult patients admitted to a tertiary medical center over a period of 27 years. Methods: We retrospectively reviewed the records of patients with a first-ever stroke in the age range of 15–45 years who were admitted to the ‘12 de Octubre’ University Hospital between 1974 and 2002. Results: 272 young adults with ischemic stroke were identified. The etiological diagnoses were: undetermined in 36% of patients, large-artery atherosclerosis in 21%, cardioembolism in 17%, non-atherosclerotic vasculopathy in 17%, and other specific etiologies in 9%. While in the first study period (1974–1988) 45% of patients were diagnosed with uncertain etiology, in the last period (1989–2002) only 26% were diagnosed with cryptogenic stroke (45% with two or more potential etiologies identified; 45% with no identified cause despite complete evaluation, and 10% with incomplete evaluation). Conclusions: The etiological diagnosis of stroke in young adults has changed over time as a result of improvements in diagnostic workup. While cryptogenic stroke was the most frequent diagnosis in the past, today specific causes (non-atherosclerotic vasculopathy, large-artery atherosclerosis, cardioembolism and hematological disorder) are identified in the majority of patients.

© 2007 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 04, 2006
Accepted: November 26, 2006
Published online: January 31, 2007
Issue release date: May 2007

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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