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Vol. 57, No. 4, 2007
Issue release date: May 2007
Section title: Original Paper
Eur Neurol 2007;57:212–218
(DOI:10.1159/000099161)

Causes of Ischemic Stroke in Young Adults, and Evolution of the Etiological Diagnosis over the Long Term

Varona J.F.a · Guerra J.M.a · Bermejo F.b · Molina J.A.b · Gomez de la Cámara A.c
Departments of aInternal Medicine, and bNeurology, and cEpidemiology Investigation Unit, University Hospital ‘12 de Octubre’, Madrid, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/4/2006
Accepted: 11/26/2006
Published online: 1/31/2007
Issue release date: May 2007

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background: Causes of ischemic stroke in young adults (15–45 years) are diverse, but undetermined etiology is common in a majority of studies. Aims: The present series study aims to evaluate causes and changes in the etiological diagnosis of ischemic stroke in young adult patients admitted to a tertiary medical center over a period of 27 years. Methods: We retrospectively reviewed the records of patients with a first-ever stroke in the age range of 15–45 years who were admitted to the ‘12 de Octubre’ University Hospital between 1974 and 2002. Results: 272 young adults with ischemic stroke were identified. The etiological diagnoses were: undetermined in 36% of patients, large-artery atherosclerosis in 21%, cardioembolism in 17%, non-atherosclerotic vasculopathy in 17%, and other specific etiologies in 9%. While in the first study period (1974–1988) 45% of patients were diagnosed with uncertain etiology, in the last period (1989–2002) only 26% were diagnosed with cryptogenic stroke (45% with two or more potential etiologies identified; 45% with no identified cause despite complete evaluation, and 10% with incomplete evaluation). Conclusions: The etiological diagnosis of stroke in young adults has changed over time as a result of improvements in diagnostic workup. While cryptogenic stroke was the most frequent diagnosis in the past, today specific causes (non-atherosclerotic vasculopathy, large-artery atherosclerosis, cardioembolism and hematological disorder) are identified in the majority of patients.

© 2007 S. Karger AG, Basel


  

Author Contacts

J.F. Varona, MD
Department of Internal Medicine, University Hospital ‘12 de Octubre’
Avda. Andalucía, km 5.4, ES–28041 Madrid (Spain)
Tel. +34 91 390 8286, Fax +34 91 390 8103
E-Mail jfva_varona@yahoo.com

  

Article Information

Received: August 4, 2006
Accepted: November 26, 2006
Published online: January 31, 2007
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 37

  

Publication Details

European Neurology

Vol. 57, No. 4, Year 2007 (Cover Date: May 2007)

Journal Editor: Bogousslavsky, J. (Montreux)
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/ENE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/4/2006
Accepted: 11/26/2006
Published online: 1/31/2007
Issue release date: May 2007

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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