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Vol. 23, No. 5, 2007
Issue release date: April 2007
Section title: Original Research Article
Dement Geriatr Cogn Disord 2007;23:281–288
(DOI:10.1159/000100850)

Cognitive Changes in Parkinson’s Disease Patients with Visual Hallucinations

Ramirez-Ruiz B. · Junque C. · Marti M.-J. · Valldeoriola F. · Tolosa E.
aInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), bDepartment of Psychiatry and Clinical Psychobiology, University of Barcelona, cParkinson’s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic Universitari, University of Barcelona, Barcelona, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 8/9/2006
Published online: 3/14/2007

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Objective: To evaluate the decline in specific neuropsychological functions in nondemented Parkinson’s disease (PD) patients with a history of visual hallucinations (VH). Methods: Twenty PD patients with VH, 20 PD patients without VH and 18 normal controls were followed up over a 1-year period and assessed for cognitive decline. Results: Forty-five percent of nondemented hallucinating PD patients developed dementia during the 1-year period between baseline and follow-up evaluations. Of the nondemented hallucinating PD patients nearly 70% showed impairment in multiple cognitive domains. The progressive decline in hallucinating PD patients affected mainly visual memory for faces and visuoperceptive-visuospatial functions. Conclusion: Our results support a fast impairment of complex visual functions in hallucinating PD patients, but also a progressive decline in multiple cognitive domains, which have been identified as a risk of developing dementia in PD.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 8/9/2006
Published online: 3/14/2007

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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