Transforming Growth Factor-β and microRNA:mRNA Regulatory Networks in Epithelial PlasticityZavadil J.a · Narasimhan M.b · Blumenberg M.c · Schneider R.J.b
aDepartment of Pathology and NYU Cancer Institute, and Departments of bMicrobiology and cDermatology, New York University School of Medicine, New York, N.Y., USA Cells Tissues Organs 2007;185:157–161 (DOI:10.1159/000101316)
Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA profiling screen in transforming growth factor-β1 (TGF-β)-induced epithelial-mesenchymal transition (EMT) in human keratinocytes, a model of epithelial cell plasticity underlying epidermal injury and skin carcinogenesis. We describe a novel EMT-specific microRNA signature that includes induction of miR-21, a candidate oncogenic microRNA associated with carcinogenesis. By integrating the microRNA screen results with target prediction algorithms and gene expression profiling data, we outline a framework for TGF-β-directed microRNA:messenger RNA (mRNA) regulatory circuitry and discuss its biological relevance for tumor progression.
|Direct payment||This item at the regular price: USD 38.00|
|Payment from account||With a Karger Pay-per-View account (down payment USD 150)
you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50