Efficacy and Safety of Galantamine in Patients with Dementia with Lewy Bodies: A 24-Week Open-Label StudyEdwards K.a, b · Royall D.c, d · Hershey L.e · Lichter D.e · Hake A.f · Farlow M.f · Pasquier F.h · Johnson S.g
aAlzheimer’s Diagnostic and Treatment Center, Bennington, Vt., bDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass., cDepartment of Psychiatry, University of Texas Health Science Center, and dAudie L. Murphy Memorial Veterans Affairs Hospital, San Antonio, Tex., eDepartment of Neurology, Buffalo Veterans Affairs Hospital, Buffalo, N.Y., fDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Ind., and gDepartment of Mathematics, Williams College, Williamstown, Mass., USA; hClinique Neurologique, EA2691, Centre Hospitalier et Universitaire, Lille, France Dement Geriatr Cogn Disord 2007;23:301–305 (DOI:10.1159/000101512)
Background: Dementia with Lewy bodies (DLB) is a common dementia of the elderly. A significant cholinergic deficit has been demonstrated that may be responsive to treatment by cholinesterase inhibitors (ChEIs). Methods: A 24-week, open-label study was designed to assess the efficacy and safety of a ChEI, galantamine, in 50 patients with DLB. Results: This study showed beneficial effects with galantamine in 2 of the 3 primary efficacy parameters. The scores on the Neuropsychiatric Inventory (NPI-12) improved by 8.24 points from baseline (p = 0.01) especially in visual hallucinations and nighttime behaviors (p = 0.004). The scores on the Clinician’s Global Impression of Change improved by 0.5 points from baseline (p = 0.01). The third primary efficacy parameter, the Cognitive Drug Research Computerized Cognitive Assessment System, was unchanged from baseline. Adverse events were generally mild and transient. Conclusion: Galantamine appears to be an effective and safe therapy for patients with DLB.
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