Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

Soluble HLA-G and Embryo Implantation: Frequently Asked Questions

Le Bouteiller P.a · Tabiasco J.a · Parinaud J.b
aINSERM U563, Hôpital Purpan, Toulouse, and bLaboratoire de Biologie de la Reproduction, Hôpital Paule de Viguier, Toulouse, France Gynecol Obstet Invest 2007;64:134–137 (DOI:10.1159/000101736)


Two major criteria are currently used for optimal human embryo selection in in vitro fertilization or intracytoplasmic sperm injection: overall morphology-based grading system and rate of fragmentation. The measurement of soluble HLA-G (sHLA-G) in human preimplantation embryo culture supernatants gives great hope that addition of such a biochemical quantitative criterion would further improve the rates of implantation. In this short review, we will examine the functional significance of this latter approach by discussing the following frequently asked questions: (1) Which sHLA-G isoform(s) might be present in the human preimplantation embryo culture supernatants? (2) Where do these sHLA-G molecules come from? (3) Why are some preimplantation embryos ‘HLA-G secretors’ and others not? (4) How might the functions exerted by sHLA-G molecules influence embryonic implantation?


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00