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Table of Contents
Vol. 64, No. 3, 2007
Issue release date: October 2007
Gynecol Obstet Invest 2007;64:134–137
(DOI:10.1159/000101736)

Soluble HLA-G and Embryo Implantation: Frequently Asked Questions

Le Bouteiller P. · Tabiasco J. · Parinaud J.
aINSERM U563, Hôpital Purpan, Toulouse, and bLaboratoire de Biologie de la Reproduction, Hôpital Paule de Viguier, Toulouse, France

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Abstract

Two major criteria are currently used for optimal human embryo selection in in vitro fertilization or intracytoplasmic sperm injection: overall morphology-based grading system and rate of fragmentation. The measurement of soluble HLA-G (sHLA-G) in human preimplantation embryo culture supernatants gives great hope that addition of such a biochemical quantitative criterion would further improve the rates of implantation. In this short review, we will examine the functional significance of this latter approach by discussing the following frequently asked questions: (1) Which sHLA-G isoform(s) might be present in the human preimplantation embryo culture supernatants? (2) Where do these sHLA-G molecules come from? (3) Why are some preimplantation embryos ‘HLA-G secretors’ and others not? (4) How might the functions exerted by sHLA-G molecules influence embryonic implantation?



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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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    External Resources

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