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DNA Variation in MSR1, RNASEL and E-Cadherin Genes and Prostate Cancer in Poland

Cybulski C.a · Wokołorczyk D.a · Jakubowska A.a · Gliniewicz B.b · Sikorski A.b · Huzarski T.a · Dębniak T.a · Narod S.A.c · Lubiński J.a
aInternational Hereditary Cancer Center, Department of Genetics and Pathology and bClinic of Urology, Pomeranian Medical University, Szczecin, Poland; cCentre for Research on Women’s Health, Toronto, Ont., Canada Urol Int 2007;79:44–49 (DOI:10.1159/000102913)


Introduction: We investigated whether or not inherited variation in MSR1, RNASEL and E-cadherin contribute to prostate cancer risk in Poland. Material and Methods: We sequenced the coding region of these three genes in individuals from Poland and identified five common DNA variants (R462Q and D541E in RNASEL, R293X and P275A in MSR1, and 2076C>T (A692A) in E-cadherin). These five variants and the –160C>A promoter change in E-cadherin were genotyped in 737 prostate cancer cases and 511 controls. Results: The frequencies of genotyped variants in MSR1, RNASEL and E-cadherin genes in cases and controls were similar. We did not see any association for the studied variants when cases were stratified by age of diagnosis, by family history, by prostate-specific antigen level at the time of diagnosis, by Gleason sore or by tumor stage. Conclusions: Inherited variation in RNASEL, MSR1 and E-cadherin genes do not seem to contribute to prostate cancer development in Poland.


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