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Vol. 51, No. 2, 2007
Issue release date: June 2007
Ann Nutr Metab 2007;51:139–145

Dairy Products, Calcium and the Risk of Breast Cancer: Results of the French SU.VI.MAX Prospective Study

Kesse-Guyot E. · Bertrais S. · Duperray B. · Arnault N. · Bar-Hen A. · Galan P. · Hercberg S.
aINSERM, U557; INRA, U1125; CNAM, EA3200; Université Paris 13; CRNH IdF, Unité de Recherche en Epidémiologie Nutritionnelle, Bobigny; bService de Radiologie, Hôpital St Antoine, Paris; cLim & Bio, Bobigny and dINA-PG, UMR 518 INRA/INAPG/ENGREF, Paris, France

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The aim was to estimate the association between dairy products (total and their subgroups), calcium intake and the risk of breast cancer. As few studies have considered menopausal status, we also investigated stratified analyses. This analysis included 3,627 women from the French SU.VI.MAX study, among whom 92 developed breast cancer during the follow-up period. Food consumption was assessed based on five 24-hour records completed during the previous 18 months to follow-up. Calcium intake was calculated using an ad-hoc food composition database. Cox proportional hazards models were used to estimate relative risk (RR), comparing 4th quartile vs. 1st quartile, and 95% confidence intervals (95% CI). A lower risk of breast cancer was observed with high total dairy product consumption in the whole population (RR = 0.55, 95% CI = 0.29–1.03, ptrend = 0.03) and among premenopausal women with a RR of 0.35 (95% CI = 0.12–0.95, ptrend = 0.01). None of these associations remained after control for calcium intake. Increasing calcium intake was inversely associated with breast cancer risk considering the whole population (RR = 0.50, 95% CI = 0.27–0.91, ptrend = 0.04) and among the subgroup of premenopausal women (RR = 0.26, 95% CI = 0.10–0.71, ptrend = 0.01) respectively. Our data support the hypothesis that dairy products, through calcium content or a correlated component, might have a negative association with the risk of breast cancer, particularly among premenopausal women.

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  1. Remontet L, Esteve J, Bouvier AM, Grosclaude P, Launoy G, Menegoz F, Exbrayat C, Tretare B, Carli PM, Guizard AV, Troussard X, Bercelli P, Colonna M, Halna JM, Hedelin G, Mace-Lesec’h J, Peng J, Buemi A, Velten M, Jougla E, Arveux P, Le Bodic L, Michel E, Sauvage M, Schvartz C, Faivre J: Cancer incidence and mortality in France over the period 1978–2000. Rev Epidemiol Sante Publique 2003;51:3–30.
  2. Key TJ, Verkasalo PK, Banks E: Epidemiology of breast cancer. Lancet Oncol 2001;2:133–140.
  3. American Institute for Cancer Research/World Cancer Research Fund: Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, American Institute for Cancer Research, 1997.
  4. Smith-Warner SA, Spiegelman D, Adami HO, Beeson WL, van den Brandt PA, Folsom AR, Fraser GE, Freudenheim JL, Goldbohm RA, Graham S, Kushi LH, Miller AB, Rohan TE, Speizer FE, Toniolo P, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hunter DJ: Types of dietary fat and breast cancer: a pooled analysis of cohort studies. Int J Cancer 2001;92:767–774.
  5. Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC: Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst 2003;95:1079–1085.
  6. Key TJ, Allen NE, Spencer EA, Travis RC: The effect of diet on risk of cancer. Lancet 2002;360:861–868.
  7. Key TJ, Allen NE, Spencer EA, Travis RC: Nutrition and breast cancer. Breast 2003;12:412–416.
  8. Hunter DJ, Spiegelman D, Adami HO, Beeson L, van den Brandt PA, Folsom AR, Fraser GE, Goldbohm RA, Graham S, Howe GR, et al: Cohort studies of fat intake and the risk of breast cancer – a pooled analysis. N Engl J Med 1996;334:356–361.
  9. McTiernan A: Behavioral risk factors in breast cancer: can risk be modified? Oncologist 2003;8:326–334.
  10. Moorman PG, Terry PD: Consumption of dairy products and the risk of breast cancer: a review of the literature. Am J Clin Nutr 2004;80:5–14.
  11. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briancon S: The SU.VI.MAX study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004;164:2335–2342.
  12. Le Moullec N, Deheeger M, Preziosi P, Montero P, Valeix P, Rolland-Cachera MF, Potier de Courcy G, Christides JP, Galan P, Hercberg S: Validation du manuel photos utilisé pour l’enquête alimentaire de l’étude SU.VI.MAX. Cah Nutr Diét 1996;31:158–164.
  13. Mennen LI, Bertrais S, Galan P, Arnault N, Potier de Courcy G, Hercberg S: The use of computerised 24 h dietary recalls in the French SU.VI.MAX study: number of recalls required. Eur J Clin Nutr 2002;56:659–665.
  14. Hercberg S: Table de composition SU.VI.MAX des aliments. Paris, Les éditions INSERM/Economica, 2005.
  15. Korn EL, Graubard BI, Midthune D: Time-to-event analysis of longitudinal follow-up of a survey: choice of the time-scale. Am J Epidemiol 1997;145:72–80.
  16. Willett W, Stampfer MJ: Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986;124:17–27.
  17. Missmer SA, Smith-Warner SA, Spiegelman D, Yaun SS, Adami HO, Beeson WL, van den Brandt PA, Fraser GE, Freudenheim JL, Goldbohm RA, Graham S, Kushi LH, Miller AB, Potter JD, Rohan TE, Speizer FE, Toniolo P, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hunter DJ: Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. Int J Epidemiol 2002;31:78–85.
  18. Shin MH, Holmes MD, Hankinson SE, Wu K, Colditz GA, Willett WC: Intake of dairy products, calcium, and vitamin D and risk of breast cancer. J Natl Cancer Inst 2002;94:1301–1311.
  19. McCullough ML, Rodriguez C, Diver WR, Feigelson HS, Stevens VL, Thun MJ, Calle EE: Dairy, calcium, and vitamin D intake and postmenopausal breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 2005;14:2898–2904.
  20. Hjartaker A, Laake P, Lund E: Childhood and adult milk consumption and risk of premenopausal breast cancer in a cohort of 48,844 women – the Norwegian women and cancer study. Int J Cancer 2001;93:888–893.
  21. Knekt P, Jarvinen R, Seppanen R, Pukkala E, Aromaa A: Intake of dairy products and the risk of breast cancer. Br J Cancer 1996;73:687–691.
  22. John EM, Schwartz GG, Dreon DM, Koo J: Vitamin D and breast cancer risk: the NHANES I epidemiologic follow-up study, 1971–1975 to 1992. National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev 1999;8:399–406.
  23. Lipkin M, Newmark HL: Vitamin D, calcium and prevention of breast cancer: a review. J Am Coll Nutr 1999;18:392S–397S.
  24. Braga C, La Vecchia C, Negri E, Franceschi S, Parpinel M: Intake of selected foods and nutrients and breast cancer risk: an age- and menopause-specific analysis. Nutr Cancer 1997;28:258–263.

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