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Vol. 58, No. 2, 2007
Issue release date: August 2007
Section title: Original Paper
Eur Neurol 2007;58:78–83
(DOI:10.1159/000103641)

Peripheral Blood Markers of Oxidative Stress in Parkinson’s Disease

Younes-Mhenni S. · Frih-Ayed M. · Kerkeni A. · Bost M. · Chazot G.
aDepartment of Neurology, University Hospital of Monastir, and bDepartment of Biophysics, University of Monastir, Monastir, Tunisia; cTrace Element Institute for UNESCO and dTrace Analysis Laboratory, Biochemistry Federation, Edouard Herriot Hospital, Lyon, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/4/2006
Accepted: 1/31/2007
Published online: 6/12/2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Oxidative stress and generation of reactive oxygen species are believed to be implicated in Parkinson’s disease (PD). Erythrocyte activity of superoxide dismutase (SOD) and catalase, the blood glutathione system, and plasma levels of thiobarbituric-acid-reactive substances (TBARS) were measured in 80 PD patients. These biochemical parameters were also measured in 29 age-matched controls. Patients with PD had significantly higher red blood corpuscle (RBC) activity of SOD. The mean RBC activity of catalase in PD patients did not differ significantly from those of controls. RBC catalase activity was significantly lower in advanced cases of PD compared to early cases. Oxidized glutathione was significantly higher in RBCs of PD patients, although there were no changes in total glutathione and reduced glutathione compared to controls. TBARS content was increased in patients with PD. Levodopa therapy, age and duration of illness did not significantly influence the measured parameters. Our study supports the previous hypothesis that oxidative stress is implicated in the pathogenesis of PD. Perspectives for treatment of PD in the future could include antioxidant therapy.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/4/2006
Accepted: 1/31/2007
Published online: 6/12/2007

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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