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Table of Contents
Vol. 7, No. 2-3, 2007
Issue release date: July 2007
Section title: Review
Free Access
Pancreatology 2007;7:115–123
(DOI:10.1159/000104236)

Effect of Ethanol on Inflammatory Responses

Implications for Pancreatitis

Szabo G.a · Mandrekar P.a · Oak S.a · Mayerle J.b
aDepartment of Medicine, University of Massachusetts Medical School, Worcester, Mass., USA; bDepartment of Gastroenterology, Endocrinology and Nutrition, Ernst-Moritz-Arndt University, Greifswald, Germany
email Corresponding Author

Gyongyi Szabo, MD, PhD

Hepatology and Liver Center, Department of Medicine

University of Massachusetts Medical Center, 364 Plantation Street LRB125

Worcester, MA 01605 (USA)

Tel. +1 508 856 5275 Fax +1 508 856 4770, E-Mail gyongyi.szabo@umassmed.edu


References

  1. Cook RT: Alcohol abuse, alcoholism and damage to the immune system: a review. Alcohol Clin Exp Res 1998;22:1927–1942.
  2. Naveau S, Raynard B, Ratziu V, Abella A, Imbert-Bismut F, Messous D, Beuzen F, Capron F, Thabut D, Munteanu M, Chaput JC, Poynard T: Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease. Clin Gastroenterol Hepatol 2005;3:167–174.
  3. Jaakola M, Sillanaukee P, Lof K, Koivula T, Nordack I: Amount of alcohol is an important determinant of the severity of acute alcoholic pancreatitis. Surgery 1994;115:31–38.
  4. Szabo G, Mandrekar P, Dolganiuc A, Catalano D, Kodys K: Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNγ levels. Alcohol Clin Exp Res 2001;25:1766–1772.
  5. Szabo G, Catalano D, White B, Mandrekar P: Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells. Alcohol Clin Exp Res 2004;28:824–828.
  6. Mandrekar P, Catalano D, Dolganiuc A, Kodys K, Szabo G: Inhibition of myeloid dendritic cell accessory cell function by alcohol correlates with reduced CD80/CD86 expression and decreased IL-12 production. J Immunol 2004;173:3398–3407.
  7. Takeda K, Akira S: TLRs in innate immunity. Int Immunol 2005;17:1–14.
  8. Yamamoto M, Akira S: TIR domain-containing adaptors regulate TLR signaling pathways. Adv Exp Med Biol 2005;560:1–9.
  9. Jarrossay D, Napolitani G, Colonna M, Sallusto F, Lanzavecchia A: Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001;31:3388–3393.
  10. Wagner H, Bauer S: All is not Toll: new pathways in DNA recognition. J Exp Med 2006;203:265–268.
  11. Vabulas RM, Ahmad-Nejad P, Ghose S, Kirschning CJ, Issels RD, Wagner H: HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 2002;277:15107–15112.
  12. Ohashi K, Burkart V, Flohe S, Kolb H: Cutting edge: heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex. J Immunol 2000;164:558–561.
  13. Dufour MC, Adamson MD: The epidemiology of alcohol-induced pancreatitis. Pancreas 2003;27:286–290.
  14. Apte MV, Wilson JS: Alcohol-induced pancreatic injury. Best Pract Res Clin Gastroenterol 2003;17:593–612.
  15. Schneider A, Singer MV: Alcoholic pancreatitis. Dig Dis 2005;23:222–231.
  16. Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS: Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models. J Gastroenterol 2003;38:623–628.
  17. Apte MV, Pirola RC, Wilson JS: Molecular mechanisms of alcoholic pancreatitis. Dig Dis 2005;23:232–240.
  18. Somogyi L, Martin S, Venkatesan T, Ulrich C: Recurrent pancreatitis: an algorithmic approach to identification and elimination of initiating factors. Gastroenterology 2001;120:944–952.
    External Resources
  19. McKim SE, Uesugi T, Raleigh JA, McClain CJ, Arteel GA: Chronic intragastic alcohol exposure causes hypoxia and oxidative stress in the rat pancreas. Arch Biochem Biophys 2003;417:34–43.
  20. Weber CK, Adler G: From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis. Pancreatology 2001;1:356–362.
  21. Siegmund SV, Brenner DA: Molecular pathogenesis of alcohol-induced hepatic fibrosis. Alcohol Clin Exp Res 2005;29:102S–109S.
  22. Verma BK, Fogarsi M, Szabo G: Down-regulation of TNF activity by acute ethanol treatment in human peripheral blood monocytes. J Clin Immunol 1993;13:8–23.
  23. Mandrekar P, Catalano D, Szabo G: Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokines 1996;8:567–577.
  24. Szabo G, Chavan S, Mandrekar P, Catalano D: Acute alcohol consumption attenuates IL-8 and MCP-1 induction in response to ex vivo stimulation. J Clin Immunol 1999;19:67–76.
  25. Szabo G, Mandrekar P, Catalano D: Inhibition of superantigen-induced T cell proliferation and monocyte IL-1β, TNF-α, and IL-6 production by acute ethanol treatment. J Leukoc Biol 1995;58:342–350.
  26. McClain CJ, Cohen DA: Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 1989;9:349–351.
  27. McClain CJ, Hill DB, Song Z, Deaciuc I, Barve S: Monocyte activation in alcoholic liver disease. Alcohol 2002;27:53–61.
  28. Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI: Circulating tumor necrosis factor, interleukin-1 and interlukin-6 concentrations in chronic alcoholic patients. Hepatology 1991;13:267–276.
  29. Hill DLB, Marsano LS, McClain CJ: Increased plasma interleukin-8 concentrations in alcoholic hepatitis. Hepatology 1993;18:576–580.
  30. Pastor CM, Pugin J, Kwak B, Chanson M, Mach F, Hadengue A, Frossard JL: Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia. Crit Care Med. 2004;32:1759–1763.
  31. Mandrekar P, Catalano D, White B, Szabo G: Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of NF-3B and induction of IL-10. Alcohol Clin Exp Res 2006;30:135–139.
  32. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N, Brenner DA, Thurman RG: Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Alcohol Clin Exp Res 2001;25:1360–1367.
  33. Oak S, Mandrekar P, Szabo G: TLR2 and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J Immunol 2006;176:7628–7635.
  34. Fortunato F, Deng X, Gates LK, McClain CJ, Bimmler D, Graf R, Whitcomb DC: Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis? Am J Physiol 2006;290:232–241.
  35. Bode C, Bode JC: Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 2003;17: 575–592.
  36. Thurman RG: II Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998;275:G605–G611.
  37. Wang X, Wu L, Wu K, Zhang R, Dong Y: Roles of endotoxin-related signaling molecules in the progression of acute necrotizing pancreatitis in mice. Pancreas 2005;31:251–257.
  38. Cario E, Golenbock DT, Visintin A, Runzi M, Gerken G, Podolsky DK: Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance. J Immunol. 2006 1;176:4258–4266.
  39. Wang P, Wu P, Siegel MI, Egan RW, Billah MM: IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J Immunol 1994;153:811–816.
  40. Pedersen N, Larsen S, Seidelin JB, Nielsen OH: Alcohol modulates circulating levels of Interleukin-6 and monocyte chemoattractant protein-1 in chronic pancreatitis. Scand J Gastroenterol 2004;3:277–282.
    External Resources
  41. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, Pandol SJ: Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998;275:G1402–G1414.
  42. Vacquero E, Gukovsky I, Zaninovic V, Gukovskaya AS, Pandol SJ: Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis. Am J Physiol 2001;280:G1197–G1208.
  43. Hosseini S, Gukovskaya A, Cheng J, Gukosky I, Pandol S: Ethanol potentiates cholecystokinin-induced but inhibits thapsigargin-induced NFκB activation in pancreatic acinar cells (abstract). Gastroenterology 2002;122:A-282.
  44. Deng X, Wang L, Elm MS, Gabazadeh D, Diorio GJ, Eagon PK, Whitcomb DC: Chronic alcohol consumption accelerates fibrosis in response to caerulein-induced pancreatitis in rats. Am J Pathol 2005;166:93–106.
  45. Szabo G, Verma BK, Fogarasi M, Catalano D: Induction of transforming growth factor-beta and prostaglandin E2 production by ethanol in human monocytes. J Leuk Biol 1992;52:602–610.