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Vol. 7, No. 2-3, 2007
Issue release date: July 2007
Section title: Original Paper
Pancreatology 2007;7:174–179
(DOI:10.1159/000104242)

Investigation of Relaxant Effects of Propofol on Sheep Sphincter of Oddi

Bagcivan I. · Gursoy S. · Yildirim M.K. · Kaya Temiz T. · Yildirim S. · Yilmaz A. · Turan M.
Departments of aPharmacology, bAnesthesiology, cInternal Medicine, Cumhuriyet University School of Medicine, Sivas, and dGerman Hospital (Universal Hospitals Group), Department of General Surgery, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/17/2006
Accepted: 12/7/2006
Published online: 6/21/2007

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN

Abstract

Background/Aims: Intravenous anesthetics are often used for conscious sedation in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincter of Oddi (SO) manometry. This study was designed to investigate the effects of propofol on sheep SO. Methods: SO rings were mounted in a tissue bath and tested for changes in isometric tension in response to propofol (10–8–10–4M) in the presence or absence of L-NAME (3 × 10–5M), a non-specific inhibitor of nitric oxide (NO) synthase; indomethacin (10–5M), an inhibitor of cyclooxygenase; glibenclamide (10–5M), an inhibitor of ATP-sensitive potassium channels; tetraethylammonium (3 × 10–4M), inhibitors of calcium-activated potassium channels; 4-aminopyridine (10–3M), a voltage-dependent potassium channel blocker. Furthermore, we investigated the Ca2+ antagonist feature of propofol in precontracted SO rings by CaCl2. Results: Carbachol (10–9–10–5M) induced concentration-dependent contraction responses in the SO rings. Propofol (10–8–10–4M) produced concentration-dependent relaxation on isolated SO rings precontracted by carbachol (10–6M). Preincubation of SO rings by L-NAME (3 × 10–5M), indomethacin (10–5M), glibenclamide (10–5M), and 4-aminopyridine (10–3M) did not produce a significant alteration on propofol-induced relaxation responses (p > 0.05), while preincubation by tetraethylammonium (3 × 10–4M) significantly decreased the propofol-induced relaxation responses (p < 0.05). Propofol (10–8–10–4M) induced concentration-dependently relaxations in precontracted isolated SO rings by CaCl2. Conclusion: The results suggest that propofol induced concentration-dependent relaxations in precontracted isolated SO rings. These relaxations are independent from NO, cyclooxygenase metabolites, and opened ATP-sensitive and voltage-dependent potassium channels. Opened Ca2+-sensitive K+ channels and inhibited L-type Ca2+ channels existing in smooth muscle by propofol can contribute to these relaxations. Propofol can be beneficial as alternative drugs for obtaining selective relaxation during SO manometry after controlled clinical studies.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/17/2006
Accepted: 12/7/2006
Published online: 6/21/2007

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


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