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Table of Contents
Vol. 74, No. 4, 2007
Issue release date: August 2007
Section title: Paper
Pathobiology 2007;74:251–258

The Genome Austria Tissue Bank (GATiB)

Asslaber M.a · Abuja P.M.a · Stark K.a, f · Eder J.f · Gottweis H.g · Trauner M.b · Samonigg H.c · Mischinger H.J.d · Schippinger W.c · Berghold A.e · Denk H.a · Zatloukal K.a
aInstitute of Pathology, bDepartment of Medicine, Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, cDivision of Oncology, Department of Internal Medicine, dDivision of General Surgery, Department of Surgery, and eInstitute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, and fFaculty of Computer Sciences, and gDepartment of Political Science, University of Vienna, Vienna, Austria
email Corresponding Author

Kurt Zatloukal, MD

Institute of Pathology, Medical University of Graz

Auenbruggerplatz 25

AT–8036 Graz (Austria)

Tel. +43 316 380 4404, Fax +43 316 384 329, E-Mail kurt.zatloukal@meduni-graz.at


  1. Hirtzlin I, Dubreuil C, Preaubert N, Duchier J, Jansen B, Simon J, Lobato De Faria P, Perez-Lezaun A, Visser B, Williams GD, Cambon-Thomsen A: An empirical survey on biobanking of human genetic material and data in six EU countries. Eur J Hum Genet 2003;11:475–488.
  2. Hagen HE, Carlstedt-Duke J: Building global networks for human diseases: genes and populations. Nat Med 2004;10:665–667.
  3. Cambon-Thomsen A: The social and ethical issues of post-genomic human biobanks. Nat Rev Genet 2004;5:866–873.
  4. Godard B, Schmidtke J, Cassiman JJ, Ayme S: Data storage and DNA banking for biomedical research: informed consent, confidentiality, quality issues, ownership, return of benefits. A professional perspective. Eur J Hum Genet 2003;11(suppl 2):S88–S122.
  5. Collins CD, Purohit S, Podolsky RH, Zhao HS, Schatz D, Eckenrode SE, Yang P, Hopkins D, Muir A, Hoffman M, McIndoe RA, Rewers M, She JX: The application of genomic and proteomic technologies in predictive, preventive and personalized medicine. Vascul Pharmacol 2006;45:258–267.
  6. Nicholson JK: Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol 2006;2:52.
    External Resources
  7. Jain KK: A critical review of the Royal Society’s report on personalized medicine. Drug Discov Today 2006;11:573–575.
  8. Dietel M, Sers C: Personalized medicine and development of targeted therapies: the upcoming challenge for diagnostic molecular pathology. A review. Virchows Arch 2006;448:744–755.
  9. Fischer HP: Towards quantitative biology: integration of biological information to elucidate disease pathways and to guide drug discovery. Biotechnol Annu Rev 2005;11:168.
  10. Corella D, Ordovas JM: Integration of environment and disease into ‘omics’ analysis. Curr Opin Mol Ther 2005;7:569–576.
  11. Vemuri GN, Aristidou AA: Metabolic engineering in the-omics era: elucidating and modulating regulatory networks. Microbiol Mol Biol Rev 2005;69:197–216.
  12. Kaiser J: Biobanks. Population databases boom, from Iceland to the USA. Science 2002;298:1158–1161.
  13. Patel AA, Gilbertson JR, Parwani AV, Dhir R, Datta MW, Gupta R, Berman JJ, Melamed J, Kajdacsy-Balla A, Orenstein J, Becich MJ: An informatics model for tissue banks – lessons learned from the Cooperative Prostate Cancer Tissue Resource. BMC Cancer 2006;6:120.
  14. Gilbertson JR, Gupta R, Nie Y, Patel AA, Becich MJ: Automated clinical annotation of tissue bank specimens. Medinfo 2004;11:607–610.
    External Resources
  15. Grizzle W, Grody WW, Noll WW, Sobel ME, Stass SA, Trainer T, Travers H, Weedn V, Woodruff K: Recommended policies for uses of human tissue in research, education, and quality control. Ad Hoc Committee on Stored Tissue, College of American Pathologists. Arch Pathol Lab Med 1999;123:296–300.
  16. Little SE, Vuononvirta R, Reis-Filho JS, Natrajan R, Iravani M, Fenwick K, Mackay A, Ashworth A, Pritchard-Jones K, Jones C: Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA. Genomics 2006;87:298–306.
  17. Devries S, Nyante S, Korkola J, Segraves R, Nakao K, Moore D, Bae H, Wilhelm M, Hwang S, Waldman F: Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors. J Mol Diagn 2005;7:65–71.
  18. Shi SR, Liu C, Balgley BM, Lee C, Taylor CR: Protein extraction from formalin-fixed, paraffin-embedded tissue sections: quality evaluation by mass spectrometry. J Histochem Cytochem 2006;54:739–743.
  19. Ikeda K, Monden T, Kanoh T, Tsujie M, Izawa H, Haba A, Ohnishi T, Sekimoto M, Tomita N, Shiozaki H, Monden M: Extraction and analysis of diagnostically useful proteins from formalin-fixed, paraffin-embedded tissue sections. J Histochem Cytochem 1998;46:397–403.
  20. Jewell SD, Srinivasan M, McCart LM, Williams N, Grizzle WH, LiVolsi V, MacLennan G, Sedmak DD: Analysis of the molecular quality of human tissues: an experience from the Cooperative Human Tissue Network. Am J Clin Pathol 2002;118:733–741.
  21. Anderson NL, Anderson NG: The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics 2002;1:845–867.
  22. Sausville EA, Burger AM: Contributions of human tumor xenografts to anticancer drug development. Cancer Res 2006;66:3351–3354.
  23. Haedicke W, Popper HH, Buck CR, Zatloukal K: Automated evaluation and normalization of immunohistochemistry on tissue microarrays with a DNA microarray scanner. Biotechniques 2003;35:164–168.
  24. Simon R, Mirlacher M, Sauter G: Tissue microarrays. Methods Mol Med 2005;114:257–268.
  25. Auray-Blais C, Patenaude J: A biobank management model applicable to biomedical research. BMC Med Ethics 2006;7:E4.
  26. Van Veen EB, Riegman PH, Dinjens WN, Lam KH, Oomen MH, Spatz A, Mager R, Ratcliffe C, Knox K, Kerr D, van Damme B, van de Vijver M, van Boven H, Morente MM, Alonso S, Kerjaschki D, Pammer J, Lopez-Guerrero JA, Llombart Bosch A, Carbone A, Gloghini A, Teodorovic I, Isabelle M, Passioukov A, Lejeune S, Therasse P, Oosterhuis JW: TuBaFrost 3: regulatory and ethical issues on the exchange of residual tissue for research across Europe. Eur J Cancer 2006;42:2914–2923.
  27. Stark K, Eder H, Zatloukal K: Priority-based K-anonymity accomplished by weighted generalisation structures. Comput Sci 2006;4081:394–404.
  28. Winkelmann BR, Marz W, Boehm BO, Zotz R, Hager J, Hellstern P, Senges J: Rationale and design of the LURIC study – a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics 2001;2:S1–S73.
  29. Riboli E, Kaaks R: The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 1997;26 Suppl 1:S6–S14.
  30. Smith BH, Campbell H, Blackwood D, Connell J, Connor M, Deary IJ, Dominiczak AF, Fitzpatrick B, Ford I, Jackson C, Haddow G, Kerr S, Lindsay R, McGilchrist M, Morton R, Murray G, Palmer CN, Pell JP, Ralston SH, St Clair D, Sullivan F, Watt G, Wolf R, Wright A, Porteous D, Morris AD: Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability. BMC Med Genet 2006;7:74.
  31. Ollier W, Sprosen T, Peakman T: UK Biobank: from concept to reality. Pharmacogenomics 2005;6:639–646.
  32. Bouchie A: Coming soon: a global grid for cancer research. Nat Biotechnol 2004;22:1071–1073.
  33. Pearson H: Summit calls for clear view of deposits in all biobanks. Nature 2004;432:426.
  34. De Montgolfier S, Moutel G, Duchange N, Callies I, Sharara L, Beaumont C, Feingold J, Herve C: Evaluation of biobank constitution and use: multicentre analysis in France and propositions for formalising the activities of research ethics committees. Eur J Med Genet 2006;49:159–167.
    External Resources
  35. Joly Y, Knoppers BM: Pharmacogenomic data sample collection and storage: ethical issues and policy approaches. Pharmacogenomics 2006;7:219–226.
  36. Hansson MG, Dillner J, Bartram CR, Carlson JA, Helgesson G: Should donors be allowed to give broad consent to future biobank research? Lancet Oncol 2006;7:266– 269.
  37. Adam D: Online tumour bank aims to offer ready route to tissues. Nature 2002;416:464.