Neonatal stroke leads to mortality and severe morbidity, but there is no effective treatment currently available. Erythropoietin (EPO) has been shown to promote cytoprotection and neurogenesis and decrease subventricular zone morphologic changes following brain injury. The long-term cellular response to EPO has not been defined, and local changes in cell fate decision may play a role in functional improvement. We performed middle cerebral artery occlusion in P10 rats. EPO treatment (5 U/g IP) significantly preserved hemispheric brain volume 6 weeks after injury. Furthermore, EPO increased the percentage of newly generated neurons while decreasing newly generated astrocytes following brain injury, without demonstrating long-term differences in the subventricular zone. These results suggest that EPO may neuroprotect and direct cell fate toward neurogenesis and away from gliogenesis in neonatal stroke.
© 2007 S. Karger AG, Basel
- Neonatal brain injury
- Neonatal stroke
- Cell fate
- Stem cell
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Fernando F. Gonzalez, MD
Departments of Neurology and Pediatrics, University of California, San Francisco
521 Parnassus Avenue, C215
San Francisco, CA 94143-0663 (USA)
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Received: September 6, 2006
Accepted after revision: October 7, 2006
Number of Print Pages : 10
Number of Figures : 5, Number of Tables : 0, Number of References : 51
Vol. 29, No. 4-5, Year 2007 (Cover Date: August 2007)
Journal Editor: Campagnoni, A.T. (Los Angeles, Calif.)
ISSN: 0378–5866 (print), 1421–9859 (Online)
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