Abstract
Ecological studies on feral populations of mice, fish and birds elucidate the functional significance of phenotypes that differ individually in their behavioral and neuroendocrine response to environmental challenge. Within a species, the capacity to cope with environmental challenges largely determines individual survival in the natural habitat. Recent studies indicate that individual variation within a species may buffer the species for strong fluctuations in the natural habitat. A conceptual framework will be presented that is based on the view that individual variation in aggressive behavior can be considered more generally as a variation in actively coping with environmental challenges. Highly aggressive individuals adopt a proactive coping style whereas low levels of aggression indicate a more passive or reactive style of coping. Coping styles have now been identified in a range of species and can be considered as trait characteristics that are stable over time and across situations. The dimension of coping style seems to be independent of an emotionality dimension. Hence, in the analysis of the proximate mechanisms of stress and adaptation, one has to consider the possibility that the mechanisms which determine the type of stress response might be independent from those underlying the magnitude of the response. The two coping styles differ in a number of important neurobiological and neuroendocrine systems. For example, proactive males differ significantly from reactive males in the homeostatic control of serotonergic activity resulting in completely opposite dose response relationships of various serotonergic drugs. The results so far show that proactive coping is characterized by a strong inhibitory control of the 5-HT neuron via its somatodendritic 5-HT1A autoreceptor. It is hypothesized that the regulation of serotonin release is causally related to coping style rather than emotionality. Understanding the functional individual variation as it occurs in nature and the underlying neurobiology and neuroendocrinology is fundamental in understanding individual vulnerability to stress related disease.
References
1.
Barf T, Korte SM, Korte-Bouws G, Sonesson C, Damsma G, Bohus B, Wikström H (1996) Potential anxiolytic properties of R-(+)-8-OSO2CF3-PAT, a 5-HT1A receptor agonist. Eur J Pharmacol 297:205–211.
2.
Benus RF, Bohus B, Koolhaas JM, Van Oortmerssen GA (1991) Behavioural differences between artificially selected aggressive and non-aggressive mice: response to apomorphine. Behav Brain Res 43:203–208.
3.
Boonstra R, Krebs CJ, Stenseth NC (1998) Population cycles in small mammals: the problem of explaining the low phase. Ecology 79:1479–1488.
4.
Bult A, Hiestand L, Van der Zee EA, Lynch CB (1993) Circadian rhythms differ between selected mouse lines: A model to study the role of vasopressin neurons in the suprachiasmatic nuclei. Brain Res Bull 32:623–627.
5.
Caramaschi D, De Boer SF, Koolhaas JM (2007) Differential role of the 5-HT1A receptor in aggressive and non-aggressive mice: An across-strain comparison. Physiol Behav 90:590–601.
6.
Chitty D (1967) The natural selection of self-regulatory behaviour in animal populations. Proc Ecol Soc Aust 2:51–78.
7.
Compaan JC, Buijs RM, Pool CW, De Ruiter AJH, Koolhaas JM (1992) Differential lateral septal vasopressin innervation in aggressive and nonaggressive male mice. Brain Res Bull 30:1–6.
8.
Cryan JF, Redmond AM, Kelly JP, Leonard BE (1997) The effects of the 5-HT1A agonist flesinoxan, in three paradigms for assessing antidepressant potential in the rat. Eur Neuropsychopharmacol 7:109–114.
9.
De Boer SF, Koolhaas JM (2003) Defensive burying in rodents: ethology, neurobiology and psychopharmacology. Eur J Pharmacol 463:145–161.
10.
De Boer SF, Koolhaas JM (2005) 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. Eur J Pharmacol 526:125–139.
11.
De Boer SF, Slangen JL, van der Gugten J (1991) Effects of buspirone and chlordiazepoxide on plasma catecholamine and corticosterone levels in stressed and nonstressed rats. Pharmacol Biochem Behav 38:299–308.
12.
De Boer SF, van der Vegt, BJ, Koolhaas JM (2003) Individual variation in aggression of feral rodent strains: a standard for the genetics of aggression and violence? Behav Genet 33:485–501.
13.
Dingemanse NJ, Both C, Drent PJ, Tinbergen JM (2004) Fitness consequences of avian personalities in a fluctuating environment. Proc Biol Sci 271:847–852.
14.
Drent PJ, van Oers K, van Noordwijk AJ (2003) Realized heritability of personalities in the great tit (Parus major). Proc R Soc Lond 270B:45–51.
15.
Henry JP, Stephens PM (1977) Stress, Health and the Social Environment: A Sociobiological Approach to Medicine. Berlin: Springer.
16.
Higley JD, Mehlman PT, Taub DM, Higley SB, Suomi SJ, Vickers JH, Linnoila M (1992) Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 49:436–441.
17.
Ison M, Fachinelli C, Rodríguez Echandía EL (1996) Effect of the i.c.v. injection of 5,7-di-hydroxytryptamine on the aggressive behavior of dominant and submissive pigeons (Columba livia). Pharmacol Biochem Behav 53:951–955.
18.
Koolhaas JM, Everts H, de Ruiter AJ, De Boer SF, Bohus B (1998) Coping with stress in rats and mice: differential peptidergic modulation of the amygdale lateral septum complex. Prog Brain Res 119:437–448.
19.
Koolhaas JM, Korte SM, De Boer SF, Van Der Vegt BJ, Van Reenen CG, Hopster H, De Jong IC, Ruis MA, Blokhuis HJ (1999) Coping styles in animals: current status in behavior and stress-physiology. Neurosci Biobehav Rev 23:925–935.
20.
Korte SM, Bouws GA, Koolhaas JM, Bohus B (1992) Neuroendocrine and behavioral responses during conditioned active and passive behavior in the defensive burying/probe avoidance paradigm: effects of ipsapirone. Physiol Behav 52:355–361.
21.
Kravitz EA, Huber R (2003) Aggression in invertebrates. Curr Opin Neurobiol 13:736–743.
22.
Lesch KP, Gutknecht L (2005) Pharmacogenetics of the serotonin transporter. Prog Neuropsychopharmacol Biol Psychiatry 29:1062–1073.
23.
Lesch KP, Merschdorf U (2000) Impulsivity, aggression, and serotonin: a molecular psychobiological perspective. Behav Sci Law 18:581–604.
24.
Miczek KA, Fish EW, De Bold JF, De Almeida RM (2002) Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology 163:434–458.
25.
Mineur YS, Belzung C, Crusio WE (2006) Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice. Behav Brain Res 175:43–50.
26.
van Oortmerssen GA, Busser J (1989) Studies in wild house mice III: Disruptive selection on aggression as a possible force in evolution. In: House Mouse Aggression: A Model for Understanding the Evolution of Social Behavior (Brain PF, Mainardi D, Parmigiani S, eds), pp 87–117. Chur: Harwood Academic Publishers.
27.
Øverli Ø, Harris CA, Winberg S (1999) Short-term effects of fights for social dominance and the establishment of dominant-subordinate relationships on brain monoamines and cortisol in rainbow trout. Brain Behav Evol 54:263–275.
28.
Parmigiani S, Palanza P, Rogers J, Ferrari PF (1999) Selection, evolution of behavior and animal models in behavioral neuroscience. Neurosci Biobehav Rev 23:957–969.
29.
Pineyro G, Blier P (1999) Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51:533–591.
30.
Roozendaal B, Wiersma A, Driscoll P, Koolhaas JM, Bohus B (1992) Vasopressinergic modulation of stress responses in the central amygdala of the Roman high-avoidance and low-avoidance rat. Brain Res 596:35–40.
31.
Saccheri I, Hanski I (2006) Natural selection and population dynamics. Trends Ecol Evol 21:341–347.
32.
Sgoifo A, De Boer SF, Haller J, Koolhaas JM (1996) Individual differences in plasma catecholamine and corticosterone stress responses of wild-type rats: relationship with aggression. Physiol Behav 60:1403–1407.
33.
Sgoifo A, Costoli T, Meerlo P, Buwalda B, Pico’-Alfonso MA, De BS, Musso E, Koolhaas JM (2005) Individual differences in cardiovascular response to social challenge. Neurosci Biobehav Rev 29:59–66.
34.
Sih A, Bell AM, Johnson JC, Ziemba RE (2004) Behavioral syndromes: an integrative overview. Q Rev Biol 79:241–277.
35.
Sluyter F, Jamot L, van Oortmerssen GA, Crusio WE (1994) Hippocampal mossy fiber distribution in mice selected for aggression. Brain Res 646:145–148.
36.
Sluyter F, van der Vlugt JJ, Van Oortmerssen GA, Koolhaas JM, van der Hoeven F, de Boer P (1996) Studies on wild house mice. VII. Prenatal maternal environment and aggression. Behav Genet 26:513–518.
37.
Steimer T, la Fleur S, Schulz PE (1997) Neuroendocrine correlates of emotional reactivity and coping in male rats from the Roman high (RHA/Verh)- and low (RLA/Verh)-avoidance lines. Behav Genet 27:503–512.
38.
Summers CH, Korzan WJ, Lukkes JL, Watt MJ, Forster GL, Øverli Ø, Höglund E, Larson ET, Ronan PJ, Matter JM, Summers TR, Renner KJ, Greenberg N (2005) Does serotonin influence aggression? Comparing regional activity before and during social interaction. Physiol Biochem Zool 78:679–694.
39.
Treit D, Pinel JPJ, Fibiger HC (1981) Conditioned defensive burying: A new paradigm for the study of anxiolytic agents. Pharmacol Biochem Behav 15:619–626.
40.
Van Der Vegt BJ, De Boer SF, Buwalda B, de Rui-ter AJH, de Jong JG, Koolhaas JM (2001) Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression. Physiol Behav 74:205–211.
41.
Van Reenen CG, Engel B, Ruis-Heutinck LFM, Van der Werf JTN, Buist WG, Jones RB, Blokhuis HJ (2004) Behavioural reactivity of heifer calves in potentially alarming test situations: a multivariate and correlational analysis. Appl Anim Behav Sci 85:11–30.
42.
Van Reenen CG, O’Connell NE, Van der Werf JTN, Korte SM, Hopster H, Jones RB, Blokhuis HJ (2005) Responses of calves to acute stress: individual consistency and relations between behavioral and physiological measures. Physiol Behav 85:557–570.
43.
Van Reenen CG, Van der Werf JTN, Bruckmaier RM, Hopster H, Engel B, Noordhuizen JP, Blokhuis HJ (2002) Individual differences in behavioral and physiological responsiveness of primiparous dairy cows to machine milking. J Dairy Sci 85:2551–2561.
44.
Veenema AH, Cremers TIFH, Jongsma ME, Steenbergen PJ, De Boer SF, Koolhaas JM (2005) Differences in the effects of 5-HT1A receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice. Psychopharmacology 178:151–160.
45.
Veenema AH, Koolhaas JM, De Kloet ER (2004) Basal and stress-induced differences in HPA axis, 5-HT responsiveness, and hippocampal cell proliferation in two mouse lines. Ann NY Acad Sci 1018:255–265.
46.
Veenema AH, Meijer OC, De Kloet ER, Koolhaas JM, Bohus BG (2003) Differences in basal and stress-induced HPA regulation of wild house mice selected for high and low aggression. Horm Behav 43:197–204.
47.
Veenema AH, Torner L, Blume A, Beiderbeck DI, Neumann ID (2007) Low inborn anxiety correlates with high intermale aggression: Link to ACTH response and neuronal activation of the hypothalamic paraventricular nucleus. Horm Behav 51:11–19.
48.
Verbeek MEM, Drent PJ, Wiepkema PR (1994) Consistent individual differences in early exploratory behavior of male great tits. Anim Behav 48:1113–1121.
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