Vol. 55, No. 3-4, 2007
Issue release date: October 2007
Editor's Choice -- Free Access
Neuropsychobiology 2007;55:132–142
(DOI:10.1159/000106055)
Original Paper
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Effect of Low-Frequency rTMS on Electromagnetic Tomography (LORETA) and Regional Brain Metabolism (PET) in Schizophrenia Patients with Auditory Hallucinations

Horacek J.a-c · Brunovsky M.a-d · Novak T.b, c · Skrdlantova L.a · Klirova M.a, b · Bubenikova-Valesova V.b · Krajca V.d · Tislerova B.a · Kopecek M.a-c · Spaniel F.a-c · Mohr P.a, c · Höschl C.a-c
aPrague Psychiatric Center, bCenter of Neuropsychiatric Studies, c3rd Medical Faculty of Charles University, and dDepartment of Neurology, Faculty Hospital Bulovka, Prague, Czech Republic
email Corresponding Author


 goto top of outline Key Words

  • Low-frequency rTMS
  • Schizophrenia
  • Auditory hallucinations
  • Brain metabolism
  • Lateralization

 goto top of outline Abstract

Background: Auditory hallucinations are characteristic symptoms of schizophrenia with high clinical importance. It was repeatedly reported that low frequency (≤1Hz) repetitive transcranial magnetic stimulation (rTMS) diminishes treatment-resistant auditory hallucinations. A neuroimaging study elucidating the effect of rTMS in auditory hallucinations has yet to be published. Objective: To evaluate the distribution of neuronal electrical activity and the brain metabolism changes after low-frequency rTMS in patients with auditory hallucinations. Methods: Low-frequency rTMS (0.9 Hz, 100% of motor threshold, 20 min) applied to the left temporoparietal cortex was used for 10 days in the treatment of medication-resistant auditory hallucinations in schizophrenia (n = 12). The effect of rTMS on the low-resolution brain electromagnetic tomography (LORETA) and brain metabolism (18FDG PET) was measured before and after 2 weeks of treatment. Results: We found a significant improvement in the total and positive symptoms (PANSS), and on the hallucination scales (HCS, AHRS). The rTMS decreased the brain metabolism in the left superior temporal gyrus and in interconnected regions, and effected increases in the contralateral cortex and in the frontal lobes. We detected a decrease in current densities (LORETA) for the beta-1 and beta-3 bands in the left temporal lobe whereas an increase was found for beta-2 band contralaterally. Conclusion: Our findings implicate that the effect is connected with decreased metabolism in the cortex underlying the rTMS site, while facilitation of metabolism is propagated by transcallosal and intrahemispheric connections. The LORETA indicates that the neuroplastic changes affect the functional laterality and provide the substrate for a metabolic effect.

Copyright © 2007 S. Karger AG, Basel


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 goto top of outline Author Contacts

Assoc. Prof. Dr. Jiri Horacek, PhD
Prague Psychiatric Center
Ustavni 91
CZ–181 03 Prague 8 (Czech Republic)
Tel. +420 2 6600 3370, Fax +420 2 6600 3366, E-Mail horacek@pcp.lf3.cuni.cz


 goto top of outline Article Information

Received: October 13, 2006
Accepted after revision: April 10, 2007
Published online: July 19, 2007
Number of Print Pages : 11
Number of Figures : 3, Number of Tables : 2, Number of References : 69


 goto top of outline Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 55, No. 3-4, Year 2007 (Cover Date: October 2007)

Journal Editor: Strik, W. (Bern)
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


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