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Vol. 55, No. 3-4, 2007
Issue release date: October 2007

A Preliminary Study of Dopamine Transporter Binding in Bipolar and Unipolar Depressed Patients and Healthy Controls

Amsterdam J.D. · Newberg A.B.
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Abstract

Objective: We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [99mTc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT levels might be higher in bipolar versus unipolar patients. Methods: [99mTc]TRODAT-1 scans were acquired from 5 bipolar and 10 unipolar patients and from 46 healthy controls. Distribution volume ratio (DVR) of [99mTc]TRODAT-1 binding affinity was calculated for regions of interest in the striatum. Results: Bipolar patients had greater DVR values compared to controls in the right posterior putamen (p = 0.001) and in the left caudate region (p = 0.007). Bipolar patients had modestly lower DAT binding in all brain regions examined, and a significantly lower DVR in the right caudate region compared to unipolar patients (p = 0.05). Conclusion: These data suggest that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and that bipolar and unipolar depressed patients may have a different pattern of striatal DAT binding.



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References

  1. Byrum CE, Ahearn EP, Krishnan KR: A neuroanatomic model for depression. Prog Neuropsychopharmacol 1999;23:175–193.
  2. Rogers MA, Bradshaw JL, Pantelis C, Phillips JG: Frontostriatal deficits in unipolar major depression. Brain Res Bull 1998;47:297–310.
  3. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG: Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 1996;379:606–612.
  4. Jaber M, Jones S, Giros B, Caron MG: The dopamine transporter: a crucial component regulating dopamine transmission. Mov Disord 1997;12:629–633.
  5. Mozley PD, Schneider JS, Acton PD, Plossl K, Stern MB, Siderowf A, Leopold NA, Li PY, Alavi A, Kung HF: Binding of [99mTc]TRODAT-1 to dopamine transporters in patients with Parkinson’s disease and in healthy volunteers. J Nucl Med 2000;41:584–589.
  6. Mozley LH, Gur RC, Mozley PD, Gur RE: Striatal dopamine transporters and cognitive functioning in healthy men and women. Am J Psychiatry 2001;158:1492–1499.
  7. Brunswick DJ, Amsterdam JD, Mozley PD, Newberg AB: Greater availability of brain dopamine transporters in major depression shown by [99mTc]TRODAT-1 SPECT imaging. Am J Psychiatry 2003;160:1836–1841.
  8. Yang YK, Yeh TL, Yoa WJ, Lee IH, Chen PS: Greater availability of dopamine transporter and no change in availability of D2/D3 receptor in major depression: a dual isotope SPECT study. Acad Conf Taiwanese Soc Psychiatry, Chung-Hua, Taiwan, November 2004.
  9. Drevets WC, Price JL, Simpson JRJ, Todd RD, Reich T, Vannier M, Raichle ME: Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997;386:824–827.
  10. Laasonen-Balk T, Kuikka J, Viinamaki H, Husso-Saastamoinen M, Lehtonen J, Tiihonen J: Striatal dopamine transporter density in major depression. Psychopharmacology (Berl) 1999;144:282–285.
  11. Meyer JH, Kruger S, Wilson AA, et al: Lower dopamine transporter binding potential in striatum during depression. Neuroreport 2001;12:4121–4125.
  12. Spitzer RL, Gibbon M, Williams JBW: Structured clinical interview for Axis I DSM-IV disorders – patient edition. Washington, American Psychiatric Press, 1994.
  13. Williams JBW: A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988;45:742–747.
  14. Malison RT, Price LH, Berman R, et al: Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry 1998;44:1090–1098.
  15. Bowden C, Cheetham SC, Lowther S, Katona CLE, Crompton MR, Horton RW: Reduced dopamine turnover in the basal ganglia of depressed suicides. Brain Res 1997;769:135–140.
  16. Sachdev P, Aniss AM: Slowness of movement in melancholic depression. Biol Psychiatry 1994;35:253–262.
  17. Caligiuri MP, Ellwanger J: Motor and cognitive aspects of motor retardation in depression. J Affect Disord 2000;57:83–93.
  18. Cummings JL: Depression and Parkinson’s disease: a review. Am J Psychiatry 1992;149:443–454.
  19. McHugh PR: The neuropsychiatry of basal ganglia disorders: a triadic syndrome and its explanation. Neuropsychiatry Neuropsychol Behav Neurol 1989;2:239–247.
  20. Anand A, Verhoeff P, Seneca N, Zoghbi SS, Seibyl JP, Charney DS, Innis RB: Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients. Am J Psychiatry 2000;157:1108–1114.
  21. Lammers CH, D’Souza U, Qin ZH, Lee SH, Yajima S, Mouradian MM: Regulation of striatal dopamine receptors by estrogen. Synapse 1999;34:222–227.
  22. Gardiner SA, Morrison MF, Mozley PD, Mozley LH, Brensinger C, Bilker W, Newberg AB, Battistini M: Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women. Am J Geriatr Psychiatry 2004;12:621–630.
  23. Kugaya A, Seneca NM, Snyder PJ, et al: Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology 2003;28:413–420.


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