Journal Mobile Options
Table of Contents
Vol. 64, No. 4, 2007
Issue release date: November 2007
Gynecol Obstet Invest 2007;64:204–207
(DOI:10.1159/000106491)

The Effect of Vitamin E on Hot Flashes in Menopausal Women

Ziaei S. · Kazemnejad A. · Zareai M.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Background: Hot flashes affect as many as 75% of menopausal women. Estrogen reliably reduces the severity of hot flashes and remain the single most effective treatment. Today, however, more and more women are seeking alternatives. Instead of hormonal therapy, women are turning to vitamins, and other over-the-counter products for relief from hot flashes. This study was undertaken to assess the effect of vitamin E on hot flashes. Method: A placebo double blind-controlled trial was conducted. After 1 week baseline period, the enrolled patients (n = 51) received placebo (identical in appearance to vitamin E softgel) daily for 4 weeks, followed by 1 week wash out and 400 IU vitamin E (softgel cap) daily for the next 4 weeks. Diary was used to measure hot flashes before and at the end of the study. Result: There were statistical significant differences in hot flashes severity score (2.37 ± 0.74, 1.80 ± 0.87) and their daily frequency (5.00 ± 3.34, 3.19 ± 2.74) after the treatments between the placebo and vitamin E therapies (p < 0.0001). Conclusion: Based on our trial, vitamin E is recommended for the treatment of hot flashes.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Morelli V, Naquin C: Alternative therapies for traditional disease states: Menopause. Am Fam Physician 2002;66:129–134.
  2. Decaro V: Alternatives to hormone therapy for the management of hot flashes. Drug Therapy Topics 2003;32:53–56.
  3. Kronenberg F, Fugh-Berman A: Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002;137:805–813.
  4. Christy C: Vitamin E in menopause. Am J Obstet Gynecol 1945;50:84–87.

    External Resources

  5. Finkler R: The effect of vitamin E in the menopause. J Clin Endocrinol Metab 1949;9:89–94.

    External Resources

  6. McLaren H: Vitamin E in menopause. Br Med J 1949;2:1378–1381.
  7. Fitzpatrick LA: Menopause and hot flashes: no easy to a complex problem. Mayo Clin Proc 2004;79:735–737.
  8. Tataryn IV, Meldrum DR, Lu KH, Frumar AM, Judd HL: LH, FSH and skin temperature during the menopausal hot flash. J Clin Endocrinol Metab 1979;49:152–154.
  9. Shanafelt TD, Barton DL, Adjei AA, Loprinzi CL: Pathophysiology and treatment of hot flashes. Mayo Clin Proc 2002;77:1207–1218.
  10. Opas EE, Gentile MA, Kimmel DB, Rodan GA, Schmidt A: Estrogenic control of thermoregulation in ERαKO and ERβKO mice. Maturitas 2006;53:210–216.
  11. Kryzhanovskii GN, Luzina NL, Iarygin KN: Alpha-tocopherol induced activation of the endogenous opioid system. Biull Eksp Biol Med 1989;108:566–567.
  12. Blatt MH, Wiesbader H, Kupperman HS: Vitamin E and climacteric syndrome. Arch Intern Med 1953;91:792–796.
  13. Barton DL, Loprinzi CL, Quella SK, et al: Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol 1998;16:495–500.


Pay-per-View Options
Direct payment This item at the regular price: USD 33.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 23.00