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Table of Contents
Vol. 215, No. 3, 2007
Issue release date: September 2007
Dermatology 2007;215:236–239

Generalized Lichen Nitidus with Involvement of the Palms following Interferon α Treatment

Scheler M. · Proelss J. · Bräuninger W. · Bieber T. · Wenzel J.
aDepartment of Dermatology, University of Bonn, Bonn, and bDepartment of Dermatology, University of Mainz, Mainz, Germany

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Lichen nitidus is an uncommon dermatosis of unknown etiology. Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon α and ribavirin. Furthermore in our patient we could show a strong lesional expression of MxA, a protein specifically induced by type I interferon. It is tempting to speculate that interferon α may be involved in the pathogenesis of lichen nitidus.

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