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Generalized Lichen Nitidus with Involvement of the Palms following Interferon α Treatment

Scheler M.a · Proelss J.a · Bräuninger W.b · Bieber T.a · Wenzel J.a
aDepartment of Dermatology, University of Bonn, Bonn, and bDepartment of Dermatology, University of Mainz, Mainz, Germany Dermatology 2007;215:236–239 (DOI:10.1159/000106582)


Lichen nitidus is an uncommon dermatosis of unknown etiology. Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon α and ribavirin. Furthermore in our patient we could show a strong lesional expression of MxA, a protein specifically induced by type I interferon. It is tempting to speculate that interferon α may be involved in the pathogenesis of lichen nitidus.


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