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Use of Electroacupuncture at ST36 to Inhibit Anaphylactic and Inflammatory Reaction in Mice

Moon P.-D.a, d · Jeong H.-J.a, d · Kim S.-J.a, d · An H.-J.a · Lee H.-J.b · Yang W.M.c · Park S.K.c · Hong S.-H.d · Kim H.-M.a · Um J.-Y.a, b
aDepartment of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, bAcupuncture and Meridian Science Research Center, cDepartment of Prescriptionology, College of Oriental Medicine, Kyung Hee University, Seoul, and dCollege of Pharmacy, Wonkwang University, Jeonbuk, Republic of Korea Neuroimmunomodulation 2007;14:24–31 (DOI:10.1159/000107285)

Abstract

Objective: Electroacupuncture (EA) has been used to treat myalgia, allergy and gastroenteropathy in Korea. To determine whether EA can treat anaphylactic and inflammatory reactions, the effect of EA was investigated in a murine model. Methods: EA stimulation of the ST36 acupoint was performed for 10 min. Using a passive cutaneous anaphylaxis (PCA) model, the antianaphylactic effects of EA were examined. Interleukin-6 and tumor necrosis factor-α were measured using the ELISA method. The level of nuclear factor (NF)-ĸB/RelA protein and NF-ĸB DNA-binding activity was determined using the Western blot analysis and the transcription factor enzyme-linked immunoassay method. Results: EA inhibits PCA and β-hexosaminidase release, IL-6 secretion on the PCA, and in addition, EA reduces NF-ĸB DNA-binding activity. Conclusion: These results indicate that EA may possess antianaphylactic and antiinflammatory properties.

 

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