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Vol. 118, No. 2, 2007
Issue release date: September 2007
Section title: Original Paper
Acta Haematol 2007;118:117–122
(DOI:10.1159/000107653)

Defective Platelet Aggregation in Myelodysplastic Syndromes

Girtovitis F.I. · Ntaios G. · Papadopoulos A. · Ioannidis G. · Makris P.E.
First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/17/2007
Accepted: 6/13/2007
Published online: 8/27/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 6

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Introduction: Hemorrhagic tendency in patients with myelodysplastic syndrome (MDS) is mainly attributed to thrombocytopenia. However, platelet function in these patients has not been thoroughly investigated. Aim: The aim of our study is to evaluate platelet function in patients with primary MDS. Methods: Platelet function was studied with aggregometry in response to ristocetin, collagen, ADP and adrenaline in 26 MDS patients and 15 healthy individuals. Results: Aggregation was defective in 21 patients (80.7%). Adrenaline was the agonist with the most profound defect (45.9%), followed by ADP (58.7%), whereas aggregation with ristocetin and collagen was at the borderline. Abnormal aggregation to all four agonists was detected in 6 patients (23%). On the contrary, aggregation results were normal in only 5 patients (19.2%). RAEB-t (refractory anemia with excess blasts in transformation) patients were most seriously affected. Conclusions: MDS patients have impaired platelet aggregation in response to one or more stimulants. Platelet aggregation was not statistically different between MDS patients at early stages of the disease (<12 months) and those at later stages (>12 months). Defective platelet aggregation is strongly related to MDS of worse prognosis. None of our patients was detected to have hyperfunctional platelets, defined as platelets aggregating spontaneously. Functional defects in MDS do not elicit hemorrhagic tendency.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/17/2007
Accepted: 6/13/2007
Published online: 8/27/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 6

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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