Objective: To determine the most effective intervention program for prevention of early childhood caries. Materials and Methods: All studies published after 1966 were identified by searching electronic databases (Medline, The Cochrane Library, Embase, Dissertation and Serfile databases) and manual searching. Studies were included if they analyzed the effect of an intervention to prevent caries in 0- to 5-year-old children, recorded caries as dmfs, dmft, dfs or dft, and utilized a randomized controlled study design. Results: The initial search produced 916 citations, 19 of which met the inclusion criteria. The quality of the articles was assessed independently by the reviewers based on randomized selection and double blinding. The 7 articles included in the actual review evaluated the effects of dental health education, prenatal fluoride administration, topical fluoride application, preventive dental programs, and use of fluoridated toothpaste. Meta-analysis was not possible because of differences in the types of intervention among the studies. Conclusion: Conclusive evidence regarding the best intervention to prevent early childhood caries could not be drawn due to the flawed design of somepapers. However, fluoride-based interventions appear to be effective in young children. More studies are required to determine the best method of delivery.
© 2007 S. Karger AG, Basel
- Dental caries
- Young children
- Caries prevention
- Early childhood caries
- Tinanoff N: Introduction to the early childhood caries conference: initial description and current understanding. Community Dent Oral Epidemiol 1998;26(suppl 1):5–7.
- Milnes AR, Rubin CW, Karpa M, Tate R: A retrospective analysis of the costs associated with the treatment of nursing caries in a remote Canadian aboriginal preschool population. Community Dent Oral Epidemiol 1993;21:253–260.
- Ismail AI: Prevention of early childhood caries. Community Dent Oral Epidemiol 1998;26(suppl 1):49–61.
- Holt RD, Winter GB, Fox B: Effects of dental health education for mothers with young children in London. Community Dent Oral Epidemiol 1985;13:148–151.
- Leverett DH, Adair SM, Vaughan BW, Proskin HM, Moss ME: Randomized clinical trial of the effect of prenatal fluoride supplements in preventing dental caries. Caries Res 1997;31:174–179.
- Linčir I, Rosin-Grget K: Caries-preventive effect of two different topical fluoride concentrations with two different frequencies of application in preschool children. Caries Res 1993;27:484–487.
- Rugg-Gunn AJ, Holloway PJ, Davies TG: Caries prevention by daily fluoride mouthrinsing. Report of a three-year clinical trial. Br Dent J 1973;135:353–360.
- Gomez SS, Weber AA: Effectiveness of a caries preventive program in pregnant women and new mothers on their offspring. Int J Paediatr Dent 2001;11:117–122.
- Winter GB, Holt RD, Williams BF: Clinical trial of a low-fluoride toothpaste for young children. Int Dent J 1989;39:227–235.
- Davies GM, Worthington HV, Ellwood RP, Bentley EM, Blinkhorn AS, Taylor GO, Davies RM:A randomized controlled trial of the effectiveness of providing free fluoride toothpaste from the age of 12 months on reducing caries in 5–6 year old children. Community Dent Health 2002;19:131–136.
- You B, Jian WW, Sheng RW, Jun Q, Wa WC, Bartizek RD, Biesbrock AR: Caries prevention in Chinese children with sodium fluoride dentifrice delivered through a kindergarten-based oral health program in China. J Clin Dent 2002;13:179–184.
- Moher D, Schulz KF, Altman DG: Improving the quality of reporting of randomized controlled trials. http://www.consort-statement.org/statement.html.
- Egger M, Juni P, Bartlett C, Holenstien F, Sterne J: How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study. Health Technol Assess 2003;7:1–76.
- Lopez L, Berkowitz R, Zlotnik H, Moss M, Weinstein P: Topical antimicrobial therapy in the prevention of early childhood caries. Pediatr Dent 1999;21:9–11.
- Ammari AB, Bloch-Zupan A, Ashley PF: Systematic review of studies comparing the anti-caries efficacy of children’s toothpaste containing 600 ppm of fluoride or less with high fluoride toothpastes of 1,000 ppm or above. Caries Res 2003;37:85–92.
Dr. Jumana B. Ammari
Pediatric Dentistry Clinic, Al-Nasr Medical Center
University of Jordan, PO Box 13930
Amman 11942 (Jordan)
Tel. +962 6 585 5032, Fax +962 6 461 7117, E-Mail email@example.com
Received: May 9, 2006
Revised: January 14, 2007
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 1, Number of References : 15
Medical Principles and Practice (International Journal of the Kuwait University Health Sciences Centre)
Vol. 16, No. 6, Year 2007 (Cover Date: October 2007)
Journal Editor: Owunwanne, A. (Kuwait)
ISSN: 1011–7571 (print), 1423–0151 (Online)
For additional information: http://www.karger.com/MPP
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