- Mild cognitive impairment
- Apolipoprotein E ε4
- Primary care
Background: Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients of general practitioners (GPs). Aims: Estimation of age-specific prevalence for original and modified concepts of MCI and their association with sociodemographic, medical and genetic (apoE ε4 genotype) factors among patients of GPs. Methods: A GP practice sample of 3,327 individuals aged 75+ was assessed by structured clinical interviews. Results: Prevalence was 15.4% (95% CI = 14.1–16.6) for original and 25.2% (95% CI = 23.7–26.7) for modified MCI. Rates increased significantly with older age. Positive associations were found for apoE ε4 allele, vascular diseases and depressive symptoms. Conclusion: MCI is frequent in elderly patients of GPs. GPs have a key position in secondary prevention and care of incipient cognitive deterioration up to the diagnosis of dementia.
Copyright © 2007 S. Karger AG, Basel
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Dipl.-Psych. Tobias Luck
Department of Psychiatry, University of Leipzig
DE–04317 Leipzig (Germany)
Tel. +49 341 972 4568, Fax +49 341 972 4539, E-Mail firstname.lastname@example.org
Further members of the AgeCoDe group: Cadja Bachmann, Gabriela Cvetanovska, Martin Dichgans, Ulrich Finckh, Anja Frenzen, Angela Fuchs, Franziska Haller, Teresa Kaufeler, Melanie Luppa, Manfred Mayer, Heinz-Peter Romberg, Hagen Sandholzer, Michael Wagner, Anja Wollny and Thomas Zimmermann.
Accepted: July 11, 2007
Published online: September 11, 2007
Number of Print Pages : 10
Number of Figures : 1, Number of Tables : 5, Number of References : 38
Dementia and Geriatric Cognitive Disorders
Vol. 24, No. 4, Year 2007 (Cover Date: September 2007)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/DEM
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