Vol. 24, No. 4, 2007
Issue release date: September 2007
Dement Geriatr Cogn Disord 2007;24:307–316
(DOI:10.1159/000108099)
Original Research Article
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Mild Cognitive Impairment in General Practice: Age-Specific Prevalence and Correlate Results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)

Luck T.a · Riedel-Heller S.G.a · Kaduszkiewicz H.b · Bickel H.c · Jessen F.d · Pentzek M.e · Wiese B.f · Koelsch H.d · van den Bussche H.b · Abholz H.-H.e · Moesch E.c · Gorfer S.g · Angermeyer M.C.a · Maier W.d · Weyerer S.g
aDepartment of Psychiatry, University of Leipzig, Leipzig, bInstitute for General Medicine, University Medical Centre, Hamburg, cDepartment of Psychiatry, Technical University of Munich, Munich, dDepartment of Psychiatry, University of Bonn, Bonn, eDepartment of General Practice, University Medical Centre, Düsseldorf, fInstitute for Biometrics, Hannover Medical School, Hannover, and gCentral Institute for Mental Health, Mannheim, Germany
email Corresponding Author


 goto top of outline Key Words

  • Mild cognitive impairment
  • Apolipoprotein E ε4
  • Comorbidity
  • Primary care

 goto top of outline Abstract

Background: Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients of general practitioners (GPs). Aims: Estimation of age-specific prevalence for original and modified concepts of MCI and their association with sociodemographic, medical and genetic (apoE ε4 genotype) factors among patients of GPs. Methods: A GP practice sample of 3,327 individuals aged 75+ was assessed by structured clinical interviews. Results: Prevalence was 15.4% (95% CI = 14.1–16.6) for original and 25.2% (95% CI = 23.7–26.7) for modified MCI. Rates increased significantly with older age. Positive associations were found for apoE ε4 allele, vascular diseases and depressive symptoms. Conclusion: MCI is frequent in elderly patients of GPs. GPs have a key position in secondary prevention and care of incipient cognitive deterioration up to the diagnosis of dementia.

Copyright © 2007 S. Karger AG, Basel


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 goto top of outline Author Contacts

Dipl.-Psych. Tobias Luck
Department of Psychiatry, University of Leipzig
Johannisallee 20
DE–04317 Leipzig (Germany)
Tel. +49 341 972 4568, Fax +49 341 972 4539, E-Mail tobias.luck@medizin.uni-leipzig.de


 goto top of outline Article Information

Further members of the AgeCoDe group: Cadja Bachmann, Gabriela Cvetanovska, Martin Dichgans, Ulrich Finckh, Anja Frenzen, Angela Fuchs, Franziska Haller, Teresa Kaufeler, Melanie Luppa, Manfred Mayer, Heinz-Peter Romberg, Hagen Sandholzer, Michael Wagner, Anja Wollny and Thomas Zimmermann.

Accepted: July 11, 2007
Published online: September 11, 2007
Number of Print Pages : 10
Number of Figures : 1, Number of Tables : 5, Number of References : 38


 goto top of outline Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 24, No. 4, Year 2007 (Cover Date: September 2007)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


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