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Vol. 118, No. 3, 2007
Issue release date: October 2007
Acta Haematol 2007;118:188–191

Primary Anaplastic Large Cell Lymphoma of the Lung

Report of Two Cases and Literature Review

Yang H.-B. · Li J. · Shen T.
aDepartment of Endocrinology and Metabolism and bDepartment of Hematology, Peking Union Medical College Hospital, Beijing, China

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To our knowledge, only eleven cases of primary anaplastic large cell lymphoma (ALCL) of the lung have previously been reported. We describe here another two cases of primary pulmonary ALCL that developed in two Chinese women. Both patients presented with insidious symptoms related to pulmonary mass or nodule lesions. A comprehensive workup failed to show disease outside the chest. CD30-positive ALCL was demonstrated by histopathological studies of the lung tissue. Both patients were treated with 6 cycles of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy and had complete remission. Primary pulmonary lymphoma is a great challenge for pneumologists since the clinical presentations and radiological findings are nonspecific. Appropriate invasive biopsy is necessary for early diagnosis.

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  1. Isaacson PG, Norton AJ: Extranodal Lymphomas. New York, Churchill Livingstone, 1994.
  2. Freeman C, Berg JW, Cutler SJ: Occurrence and prognosis of extranodal lymphomas. Cancer1972;29:252–260.
  3. Habermann TM, Ryu JH, Inwards DJ, Kurtin PJ: Primary pulmonary lymphoma. Semin Oncol 1999;26:307–315.
  4. Miller DL, Allen MS: Rare pulmonary neoplasms. Mayo Clin Proc1993;68:492–498.
  5. Chott A, Kaserer K, Augustin I, Vesely M, Heinz R, Oehlinger W, Hanak H, Radaszkiewicz T: Ki-1-positive large cell lymphoma: a clinicopathologic study of 41 cases. Am J Surg Pathol 1990;14:439–448.
  6. Chadburn A, Cesarman E, Jagirdar J, Subar M, Mir RN, Knowles DM: CD30 (Ki-1) positive anaplastic large cell lymphomas in individuals infected with the human immunodeficiency virus. Cancer 1993;72:3078–3090.
  7. Rush WL, Andriko JA, Taubenberger JK, Nelson AM, Abbondanzo SL, Travis WD, Koss MN: Primary anaplastic large cell lymphoma of the lung: a clinicopathologic study of five patients. Mod Pathol 2000;13:1285–1292.
  8. Kim JH, Lee SH, Park J, Kim HY, Lee S, Park JO, Kim K, Kim WS, Jung CW, Park YS, Im YH, Kang WK, Lee MH, Park K, Han JH, Ko YH: Primary pulmonary non-Hodgkin’s lymphoma. Jpn J Clin Oncol 2004;34:510–514.
  9. Guerra J, Echevarria-Escudero M, Barrio N, Velez-Rosario R: Primary endobronchial anaplastic large cell lymphoma in a pediatric patient. P R Health Sci J 2006;25:159–161.
  10. Cerimagic Z, Guska S, Banjanovic B: A case of T/null anaplastic large cell lymphoma arising in lung. Bosn J Basic Med Sci 2006;6:34–37.
  11. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds): World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. Lyon, IARC Press, 2001.
  12. Ahmed S, Kussick SJ, Siddiqui AK, Bhuiya TA, Khan A, Sarewitz S, Steinberg H, Sison CP, Rai KR: Bronchial-associated lymphoid tissue lymphoma: a clinical study of a rare disease. Eur J Cancer 2004;40:1320–1326.
  13. Cadranel J, Wislez M, Antoine M: Primary pulmonary lymphoma. Eur Respir J 2002;20:750–762.
  14. Ferraro P, Trastek VF, Adlakha H, Deschamps C, Allen MS, Pairolero PC: Primary non-Hodgkin’s lymphoma of the lung. Ann Thorac Surg2000;69:993–997.
  15. Burdine J, Joyce LD, Plunkett MB, Inampudi S, Kaye MG, Dunn DH: Feasibility and value of video-assisted thoracoscopic surgery wedge excision of small pulmonary nodules in patients with malignancy. Chest2002;122:1467–1470.

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