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Vol. 24, No. 5, 2007
Issue release date: October 2007
Section title: Original Research Article
Dement Geriatr Cogn Disord 2007;24:389–395
(DOI:10.1159/000109938)

Increased Saliva Cortisol Awakening Response in Patients with Mild Cognitive Impairment

Lind K. · Edman Å. · Nordlund A. · Olsson T. · Wallin A.
aInstitute of Neuroscience and Physiology, Sahlgrenska Academy, Göteborg University, Mölndal, and bDepartment of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 2/27/2007
Published online: 10/17/2007

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: It is unknown whether HPA-axis dysfunction is present in patients with mild cognitive impairment (MCI). The aim of the present study was to investigate whether cortisol levels are elevated among patients with MCI and/or whether the individuals have adequate feedback control of their HPA axis. Material and Methods: 27 patients with MCI and 15 healthy controls were included in the study. Saliva samplings were performed 5 times a day before intake of 0.5 mg dexamethasone, and 5 times a day after intake of dexamethasone, respectively. Results: Significantly higher cortisol levels were found 15 min after awakening among patients with MCI in comparison with the controls, both before and after dexamethasone administration (p < 0.05). Also, the ratio between cortisol at awakening time and 15 min after awakening was lower in the patient group after dexamethasone administration (p < 0.05). There were no significant differences in basal cortisol levels before or after dexamethasone between groups. Conclusion: The results indicate that there is an HPA-axis disturbance, with normal basal cortisol levels and increased awakening response among patients with MCI. The dissociation between basal values and the awakening response may be of pathophysiological importance for the cognitive impairment.


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 2/27/2007
Published online: 10/17/2007

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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