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Table of Contents
Vol. 68, Suppl. 5, 2007
Issue release date: December 2007
Section title: Adult Workshop 3
Horm Res 2007;68:166–172
(DOI:10.1159/000110617)

Excess Mortality in Acromegaly

Holdaway I.M.
Department of Endocrinology, Greenlane Clinical Centre, Auckland City Hospital, Auckland, New Zealand

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Article / Publication Details

First-Page Preview
Abstract of Adult Workshop 3

Published online: 12/10/2007

Number of Print Pages: 7
Number of Figures: 8
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background: Increased production of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in patients with acromegaly is associated with a twofold increase in mortality compared with the general population. The range of standardised mortality rates in various studies ranges from 1.2 to 3.6. Predictors of Mortality: Multivariate analysis has indicated that post-treatment serum GH levels and, in a number of studies, serum IGF-I levels are the most powerful predictors of outcome. Normal IGF-I concentrations and random GH levels <2.5 µg/l measured by polyclonal radioimmunoassay result in optimal outcome. Other factors adversely influencing mortality include hypertension and a long interval between onset of the disorder and diagnosis. Conclusions: Analysis of recent reports suggests that adoption of treatment guidelines with appropriate post-treatment target ranges for GH and IGF-I, together with the availability of newer methods to control GH oversecretion, has significantly improved patient outcomes.


Article / Publication Details

First-Page Preview
Abstract of Adult Workshop 3

Published online: 12/10/2007

Number of Print Pages: 7
Number of Figures: 8
Number of Tables: 2

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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