Journal Mobile Options
Table of Contents
Vol. 18, No. 5-6, 1996
Issue release date: 1996
Dev Neurosci 1996;18:426–433

Respective Roles of Glucose and Ketone Bodies as Substrates for Cerebral Energy Metabolism in the Suckling Rat

Nehlig A.
INSERM U 398, Faculté de Médecine, Strasbourg, France

Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in


The postnatal evolution of local cerebral metabolic rates for glucose (LCM-Rglcs) and of regional rates of cerebral uptake of β-hydroxybutyrate (βHB) were studied in the suckling rat between postnatal days (P) 10 and 21. LCM-Rglcs were low and homogeneous at P10. They increased significantly in 4 auditory regions between P10 and P14 at the time of maturation of the auditory function. Between P14 and P17, they increased further in 2 auditory regions, in 1 visual area, the lateral geniculate nucleus, and 3 limbic and 3 motor areas. These increases occurred simultaneously with the maturation of vision and with the development of the rat locomotion and behavioral activities. Between P17 and P21, LCMRglcs increased in all areas studied. Conversely to the function-related increases in LCMRglcs, regional rates of cerebral PHB uptake showed an overall increase between P10 and P14, stayed very high until P17 and did not correlate with the maturation of the rat behavior. Between P17 and P21, rates of cerebral pHB uptake decreased significantly in all regions studied. In conclusion, it appears that, even in the rat whose cerebral metabolic activity depends upon both glucose and ketone bodies during suckling, postnatal increases in LCMRglcs represent a signal of the acquisition of new functions and neurological competence.

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Pay-per-View Options
Direct payment This item at the regular price: USD 9.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 8.00