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Vol. 16, No. 2-3, 2008
Issue release date: February 2008
Section title: Paper
Neurosignals 2008;16:183–193

Brain-Derived Neurotropic Factor/TrkB Signaling in the Pathogenesis and Novel Pharmacotherapy of Schizophrenia

Pillai A.
Department of Psychiatry and Health Behavior, Medical College of Georgia and Medical Research Service Line, Veterans Affairs Medical Center, Augusta, Ga., USA
email Corresponding Author

Anilkumar Pillai

Medical Research Service (242), Veterans Affairs Medical Center, 5B-102

1 Freedom Way

Augusta, GA 30904 (USA)

Tel. +1 706 733 0188, ext. 2480, Fax +1 706 823 3949, E-Mail


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    External Resources

  136. Young G, Conquer J: Omega–3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev 2005;45:1–28.
  137. Du Bois TM, Deng C, Huang HF: Membrane phospholipid composition, alterations in neurotransmitter systems and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:878–888.
  138. Rao JS, Ertley RN, Lee HJ, DeMar JC Jr, Arnold JT, Rapoport SI, Bazinet RP: n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry 2007;12:36–46.
  139. Arvindakshan M, Ghate M, Ranjekar PK, Evans DR, Mahadik SP: Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophr Res 2003;62:195–204.