Background/Aims: Gait speed is cross-sectionally associated with attention and psychomotor speed in older community dwellers. It is unclear if gait speed predicts decline in these cognitive domains over time. Methods: Usual gait speed (m/s) over 6 m was measured at baseline in 2,776 Health, Aging and Body Composition Study participants (mean age ± SD 73.5 ± 2.8 years, 53% women, 37% blacks). The Digit Symbol Substitution Test (DSST) was administered at baseline and after 5 years to assess attention and psychomotor speed. We used multivariate logistic regression models to calculate the risk of DSST 5-year decline [>1 SD from mean change (9 points)] across quartiles of gait speed, adjusting for demographics, weight, physical activity, comorbidities, depression and Modified Mini-Mental State Examination. Results: After 5 years, 389 (17.1%) participants declined in DSST. Compared to those in the highest quartile of gait speed (>1.35 m/s), participants in the lowest quartile (<1.05 m/s) were more likely to decline in DSST independently of the considered covariates (OR 1.74, 95% CI 1.21–2.51, adjusted p for trend across quartiles = 0.006). Conclusions: In this cohort of older community dwellers, gait speed independently predicted a decline in DSST after 5 years.
© 2007 S. Karger AG, Basel
- Gait speed
- Psychomotor speed
- Elderly community dwellers
- Cognitive decline
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Marco Inzitari, MD
Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh
130 N Bellefield St, Room 518
Pittsburgh, PA 15213 (USA)
Tel. +1 412 383 1305, Fax +1 412 383 1308, E-Mail firstname.lastname@example.org
Published online: November 27, 2007
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 32
Vol. 29, No. 3-4, Year 2007 (Cover Date: February 2008)
Journal Editor: Feigin, V.L. (Auckland)
ISSN: 0251–5350 (Print), eISSN: 1423–0208 (Online)
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