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Vol. 1, No. 6, 2007
Issue release date: January 2008
Section title: Original Article
Sex Dev 2007;1:347–352
(DOI:10.1159/000111766)

Chromosome Abnormalities and Yq Microdeletions in Infertile Italian Couples Referred for Assisted Reproductive Technique

Marchina E. · Imperadori L. · Speziani M. · Omodei U. · Tombesi S. · Barlati S.
aBiology and Genetics Unit, Department of Biomedical Sciences and Biotechnologies, and bMedical Assisted Reproduction Centre, Spedali Civili di Brescia, University of Brescia, Brescia, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 8/6/2007
Accepted: 9/19/2007
Published online: 1/18/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-5425 (Print)
eISSN: 1661-5433 (Online)

For additional information: http://www.karger.com/SXD

Abstract

This study analyses the prevalence of karyotype aberrations and Yq microdeletions in infertile couples undergoing intracytoplasmic sperm injection (ICSI). Before undergoing ICSI, each partner of 470 infertile couples was screened for karyotype aberrations by QFQ-banding technique on peripheral blood lymphocytes; male partners were also screened for Yq microdeletions. In 2.55% of the couples karyotype aberrations were found including numerical and structural alterations of autosomes and sex chromosomes. The female group had a high prevalence of low-level sex chromosome mosaicism (1.28%) and 5 cases of structural autosomal abnormalities (1.06%). The male group had 7 structural abnormalities of the autosomes (1.49%), 2 supernumerary marker chromosomes (0.42%), one case of low level gonosomal mosaicism (0.21%), and 2 cases of Y chromosome inversion (0.42%). Eight cases of Yq microdeletions (1.70%) were also found. Screening for genetic factors, chromosomal abnormalities and Yq microdeletions is indicated for couples undergoing assisted reproductive techniques due to the higher prevalence of these factors in infertile couples compared to the population as a whole although different chromosome aberrations have been reported elsewhere.


Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: 8/6/2007
Accepted: 9/19/2007
Published online: 1/18/2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-5425 (Print)
eISSN: 1661-5433 (Online)

For additional information: http://www.karger.com/SXD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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    External Resources

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