Journal Mobile Options
Table of Contents
Vol. 13, No. 2, 2008
Issue release date: February 2008
Audiol Neurotol 2008;13:113–122
(DOI:10.1159/000111783)

Neuro-Otological Findings in Patients with Migraine- and Nonmigraine-Related Dizziness

Vitkovic J. · Paine M. · Rance G.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

This study presents the neuro-otological findings of 523 patients attending a tertiary vestibular clinic with migraine- and nonmigraine-related dizziness. Subjects were categorized into one of 4 groups, definite migrainous vertigo, probable migrainous vertigo, vestibular disorder coexisting with migraine and nonmigraine-related dizziness. No notable relationship was found between the numbers of abnormal findings between the groups for the majority of the neuro-otological tests. However, there was a significant trend in emetic response to caloric testing. The definite migrainous vertigo group were at least 4 times more likely to be nauseous to caloric testing than any other migraine category. This difference was independent of the magnitude of caloric responses between the emetic migraine groups. While further investigation is required, this study has potentially identified that nauseous/emetic response to caloric stimulation may be a distinguishing factor between migrainous vertigo and other vestibular disorders including those with a coexisting history of migraine.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Ambrosini A, de Noordhout AM, Sandor PS, Schoenen J: Electrophysiological studies in migraine: a comprehensive review of their interest and limitations. Cephalalgia 2003a;23(suppl 1):13–31.
  2. Ambrosini A, Rossi P, De Pasqua V, Pierelli F, Schoenen J: Lack of habituation causes high intensity dependence of auditory evoked cortical potentials in migraine. Brain 2003b;126:2009–2015.
  3. Aragones JM, Fortes-Rego J, Fuste J, Cardozo A: Migraine: an alternative in the diagnosis of unclassified vertigo. Headache 1993;33:125–128.
  4. Baker A, Enticott JC: Retrospective study of the subjective symptoms and objective results in 1000 vestibular patients. Aust N Z J Audiol 2005;27:42–50.

    External Resources

  5. Battista RA: Audiometric findings of patients with migraine-associated dizziness. Otol Neurotol 2004;25:987–992.
  6. Brey RL: Both migraine and motion sickness may be due to low brain levels of serotonin. Neurology 2005;65:620–622.
  7. Cass SP, Furman JM, Ankerstjerne K, Balaban C, Yetiser S, Aydogan B: Migraine-related vestibulopathy. Ann Otol Rhinol Laryngol 1997;106:182–189.
  8. Colebatch JG, Halmagyi GM, Skuse NF: Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 1994;57:190–197.
  9. Crevits L, Bosman T: Migraine-related vertigo: towards a distinctive entity. Clin Neurol Neurosurg 2005;107:82–87.
  10. Cutrer FM, Baloh RW: Migraine-associated dizziness. Headache 1992;32:300–304.
  11. de Tommaso M, Guido M, Libro G, Losito L, Difruscolo O, Sardaro M, Puca FM: Interictal lack of habituation of mismatch negativity in migraine. Cephalalgia 2004;24:663–668.
  12. Dieterich M, Brandt T: Episodic vertigo related to migraine (90 cases): vestibular migraine? J Neurol 1999;246:883–892.
  13. Drummond PD: Triggers of motion sickness in migraine sufferers. Headache 2005;45:653–656.
  14. Enticott JC, Dowell RC, O’Leary SJ: A comparison of the monothermal and bithermal caloric tests. J Vestib Res 2003;13:113–119.
  15. Enticott JC, O’Leary SJ, Briggs RJS: Effects of vestibulo-ocular reflex exercises on vestibular compensation after vestibular schwannoma surgery. Otol Neurotol 2005;26:265–269.
  16. Furman JM, Balaban CD, Jacob RG, Marcus DA: Migraine-anxiety related dizziness (MARD): a new disorder? J Neurol Neurosurg Psychiatry 2005;76:1–8.
  17. Furman JM, Jacob RG: A clinical taxonomy of dizziness and anxiety in the otoneurological setting. J Anxiety Disord 2001;15:9–26.
  18. Furman JM, Marcus DA, Balaban CD: Migrainous vertigo: development of a pathogenetic model and structured diagnostic interview. Curr Opin Neurol 2003;16:5–13.
  19. Goadsby PJ: Migraine pathophysiology. Headache 2005;45(suppl 1):14–24.

    External Resources

  20. Goadsby PJ: Recent advances in the diagnosis and management of migraine. BMJ 2006;332:25–29.
  21. Goadsby PJ: Recent advances in understanding migraine mechanisms, molecules and therapeutics. Trends Mol Med 2007;13:39–44.
  22. Goadsby PJ, Zagami AS, Lambert GA: Neural processing of craniovascular pain: a synthesis of the central structures involved in migraine. Headache 1991;31:365–371.
  23. Harker LA, Rassekh C: Migraine equivalent as a cause of episodic vertigo. Laryngoscope 1988;98:160–164.
  24. Harno H, Hirvonen T, Kaunisto MA, Aalto H, Levo H, Isotalo E, Kallela M, Kaprio J, Palotie A, Wessman M, Farkkila M: Subclinical vestibulocerebellar dysfunction in migraine with and without aura. Neurology 2003;61:1748–1752.
  25. Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders, ed 2. Cephalalgia 2004;24(suppl 1):9–160.

    External Resources

  26. Ishizaki K, Mori N, Takeshima T, Fukuhara Y, Ijiri T, Kusumi M, Yasui K, Kowa H, Nakashima K: Static stabilometry in patients with migraine and tension-type headache during a headache-free period. Psychiatry Clin Neurosci 2002;56:85–90.
  27. Jacob RG, Furman JM: Psychiatric consequences of vestibular dysfunction. Curr Opin Neurol 2001;14:41–46.
  28. Jongkees LB: Thermic test and electronystagmography. Acta Otorhinolaryngol Belg 1965;19:455–464.
  29. Judit A, Sandor PS, Schoenen J: Habituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack. Cephalalgia 2000;20:714–719.
  30. Kayan A, Hood JD: Neuro-otological manifestations of migraine. Brain 1984;107:1123–1142.
  31. Lance J, Goadsby PJ: Mechanism and Management of Headache, ed 7. New York, Elsevier, 2005.
  32. Lanteri-Minet M, Radat F, Chautard M-H, Lucas C: Anxiety and depression associated with migraine: influence on migraine subjects’ disability and quality of life, and acute migraine management. Pain 2005;118:3:319–326.
  33. Lauritzen M: Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994;117:199–210.
  34. Lauritzen M, Skyhoj Olsen T, Lassen NA, Paulson OB: Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 1983;13:633–641.
  35. Leao AP: Spreading depression of activity in cerebral cortex. J Neurophysiol. 1944;7:359–390.

    External Resources

  36. Lightfoot GR: The origin of order effects in the results of the bi-thermal caloric test. Int J Audiol 2004;43:276–286.
  37. Marcus DA, Furman JM, Balaban CD: Motion sickness in migraine sufferers. Expert Opin Pharmacother 2005;6:2691–2697.
  38. Marriage J, Barnes NM: Is central hyperacusis a symptom of 5-hydroxytryptamine (5-HT) dysfunction? J Laryngol Otol 1995;109:915–921.
  39. Modrovich NJ: Sinusoidal Harmonic Acceleration, Velocity-Step and Ocular-Motor Tests: A Normative Data Study. Melbourne, The University of Melbourne, 1999.
  40. Nagaratnam N, Ip J, Bou-Haidar P: The vestibular dysfunction and anxiety disorder interface: a descriptive study with special reference to the elderly. Arch Gerontol Geriatr 2005;40:253–264.
  41. Neuhauser HK: Epidemiology of vertigo. Curr Opin Neurol 2007;20:40–46.
  42. Neuhauser HK, Lempert T: Diagnostic criteria for migrainous vertigo. Acta Otolaryngol 2005;125:1247–1248.
  43. Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T: The interrelations of migraine, vertigo, and migrainous vertigo. Neurology 2001;56:436–441.
  44. Oedegaard KJ, Neckelmann D, Mykletun A, Dahl AA, Zwart JA, Hagen K, Fasmer OB: Migraine with and without aura: association with depression and anxiety disorder in a population-based study. The HUNT Study. Cephalalgia 2006;26:1–6.
  45. Olsson JE: Neurotologic findings in basilar migraine. Laryngoscope 1991;101(suppl 52):1–41.
  46. Pearce J: A Comparison of Air and Water Caloric Testing: Responses in Normal Subjects. Melbourne, The University of Melbourne, 1999.
  47. Pollak L, Klein C, Rafael S, Vera K, Rabey JM: Anxiety in the first attack of vertigo. Otolaryngol Head Neck Surg 2003;128:829–834.
  48. Savundra PA, Carroll JD, Davies RA, Luxon LM: Migraine-associated vertigo. Cephalalgia 1997;17:505–510.
  49. Schoenen J: Cortical electrophysiology in migraine and possible pathogenetic implications. Clin Neurosci 1998;5:10–17.
  50. Shupak A, Gordon CR: Motion sickness: advances in pathogenesis, prediction, prevention, and treatment. Aviat Space Environ Med 2006;77:1213–1223.
  51. Silberstein SD: Migraine pathophysiology and its clinical implications. Cephalalgia 2004;24(suppl 2):2–7.
  52. Sturzebecher E, Kevanishvili Z, Werbs M, Meyer E, Schmidt D: Interpeak intervals of auditory brainstem response, interaural differences in normal-hearing subjects and patients with sensorineural hearing loss. Scand Audiol 1985;14:83–87.
  53. Szirmai A, Kisely M, Nagy G, Nedeczky Z, Szabados EM, Toth A: Panic disorder in otoneurological experience. Int Tinnitus J 2005;11:77–80.

    External Resources

  54. Thomas T: An Investigation into Stimulus Parameters & Response Variability in Extra-Tympanic Electrocochleography: A Normal Study. Melbourne, The University of Melbourne, 2002.
  55. Trampevski J: Vestibular Evoked Myogenic Potentials (VEMPs) Using Ipsilateral Sternocleidomastoid Muscle Activation. A Normative Data Study. Melbourne, The University of Melbourne, 2004.
  56. van der Schoot M: Vestibular Evoked Myogenic Potentials (VEMP). Normative Data Study. Melbourne, The University of Melbourne, 2003.
  57. Wang W, Schoenen J: Interictal potentiation of passive ‘oddball’ auditory event-related potentials in migraine. Cephalalgia 1998;18:261–265.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50