- Neuropsychiatric symptoms
- Mild cognitive impairment, early symptoms
Background: Mild cognitive impairment (MCI) is an etiologically heterogeneous condition that is characterized by cognitive changes without impairment of activities of daily living and insufficient to represent dementia. MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI. Methods: We executed a PubMed search for articles on the neuropsychiatric manifestations in MCI and reviewed their findings. Results: Behavioral abnormalities are reported in 35–75% of MCI patients with the most common being depression, apathy, anxiety and irritability. The observed variability in symptom prevalence can be explained by the different sampling methods, MCI diagnostic criteria and behavioral instruments used. There is a compelling body of evidence that MCI patients with behavioral features are more prone to develop Alzheimer’s disease (AD) than patients without these features. Conclusions: Neuropsychiatric symptoms are common features of MCI. The behavioral changes observed in MCI are similar to those of AD and may help identify the subgroup of MCI patients with prodromal AD. Large prospective longitudinal studies would greatly contribute to our understanding of the epidemiology, diagnostic and prognostic value of the neuropsychiatric features in MCI.
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Liana G. Apostolova, MD
Alzheimer’s Disease Research Center
10911 Weyburn, 2nd floor
Los Angeles, CA 90095 (USA)
Tel. +1 310 794 2551, Fax +1 310 794 3148, E-Mail firstname.lastname@example.org
Accepted: November 2, 2007
Published online: December 14, 2007
Number of Print Pages : 12
Number of Figures : 0, Number of Tables : 3, Number of References : 50
Dementia and Geriatric Cognitive Disorders
Vol. 25, No. 2, Year 2008 (Cover Date: February 2008)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (Print), eISSN: 1421–9824 (Online)
For additional information: http://www.karger.com/DEM
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