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Vol. 72, No. 3-4, 2007
Issue release date: January 2008
Oncology 2007;72:147–151

Pegylated Liposomal Doxorubicin (Caelyx®) in Metastatic Breast Cancer: A Community-Based Observation Study

Salzberg M. · Thürlimann B. · Hasler U. · Delmore G. · von Rohr A. · Thürlimann A. · Ruhstaller T. · Stopatschinskaja S. · von Moos R.
aPharma Brains, Basel, bKantonsspital, St. Gallen, cKantonsspital, Frauenfeld, dKlinik Hirslanden, Zürich, eEssex Chemie AG, Lucerne, and fKantonsspital Graubünden, Chur, Switzerland

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Objectives: Pegylated liposomal doxorubicin (PLD) has improved therapy options significantly, as it causes less myelosuppression, nausea, vomiting, and alopecia than conventional doxorubicin, while maintaining efficacy. The goal of this survey was to determine whether the use of PLD in a community-based patient group is comparable regarding chemotherapeutic doses and side effects to preselected study patients. Methods: 100 questionnaires were randomly sent to Swiss oncologists in private practices, general hospitals and university hospitals. Results: The patient cohort was heterogeneous with respect to prior treatments. PLD was an active agent in metastatic breast cancer and was well tolerated by the majority of patients. The most common non-hematological side effects were hand-foot syndrome (HFS) and mucositis while only patients receiving a dose of 50 mg/m2 (recommended dose) experienced grade 4 HFS. The reported mean dose of PLD was 38.5 mg/m2. Conclusions: This community-based observational study supports previous reports indicating that PLD at a median dose of ≤40 mg/m2 every 4 weeks is an active, well-tolerated agent in non-selected, pretreated patients with metastatic breast cancer.

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.


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