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Table of Contents
Vol. 216, No. 3, 2008
Issue release date: March 2008
Section title: Clinical and Laboratory Investigations
Dermatology 2008;216:205–212
(DOI:10.1159/000112927)

Three-Dimensional Melanin Distribution of Acral Melanocytic Nevi Is Reflected in Dermoscopy Features: Analysis of the Parallel Pattern

Kimoto M. · Sakamoto M. · Iyatomi H. · Tanaka M.
Departments of aDermatology and bPathology, Keio University School of Medicine, cDepartment of Electronic Informatics, Hosei University Faculty of Engineering, and dDepartment of Dermatology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 5/2/2007
Accepted: 10/8/2007
Published online: 1/9/2008

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns. Aim: To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy. Methods: A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed. Results: Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion. Conclusion: Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 5/2/2007
Accepted: 10/8/2007
Published online: 1/9/2008

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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