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Table of Contents
Vol. 72, No. 3-4, 2007
Issue release date: January 2008
Section title: Clinical Study
Oncology 2007;72:243–247
(DOI:10.1159/000113015)

High Incidence of Familial Gastric Cancer in Tuscany, a Region in Italy

Roviello F. · Corso G. · Pedrazzani C. · Marrelli D. · De Falco G. · Suriano G. · Vindigni C. · Berardi A. · Garosi L. · De Stefano A. · Leoncini L. · Seruca R. · Pinto E.
aDepartment of Human Pathology and Oncology, bDivision of Surgical Oncology, University of Siena, Siena, Italy; cCollege of Science and Technology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pa., USA; dInstitute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 1/31/2007
Accepted: 7/9/2007
Published online: 1/10/2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objectives: Only 1% of diffuse gastric cancers occur in families with autosomal dominant gastric cancer susceptibility. Germline mutations in the E-cadherin gene account for the hereditary diffuse gastric cancer (HDGC) syndrome. We studied a large cohort of gastric cancer patients from Tuscany, a region in Italy, to evaluate the presence of familial clustering of gastric cancer. Methods: 238 pedigrees were retrospectively studied by structured interviews. All probands with diagnosed gastric cancer were contacted in-person or by phone and tumor types were assessed in first- and second-degree relatives. Familial aggregation was investigated in order to search for families with suspected HDGC. Results: Familial aggregation for gastric cancer was observed in 79 of 238 cases (33.2%). Among these, there were 64 families (81%) with one gastric cancer other than the proband, 10 families with two gastric cancers (12.7%) and 5 families with three gastric cancers (6.3%). Fourteen families fulfilled the HDGC clinical criteria, one of them presenting with a pathogenic germline mutation in the E-cadherin gene (7.1%). Conclusions: The prevalence of familial HDGC appears extremely high. Since only one pathogenic germline mutation was noted in a family fulfilling the HDGC clinical criteria, factors other than E-cadherin gene mutations may contribute to the familial clustering of HDGC.


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 1/31/2007
Accepted: 7/9/2007
Published online: 1/10/2008

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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