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Dement Geriatr Cogn Disord 2008;25:206–211

Psychotic Symptoms in Frontotemporal Dementia: Prevalence and Review

Mendez M.F.a, b, c · Shapira J.S.a · Woods R.J.a, c · Licht E.A.a, c · Saul R.E.a, c
Departments of aNeurology and bPsychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, and cNeurobehavior Unit, VA Greater Los Angeles Healthcare System, Los Angeles, Calif., USA
email Corresponding Author

 goto top of outline Key Words

  • Frontotemporal dementia
  • Psychosis
  • Delusions
  • Hallucinations
  • Paranoia
  • Alzheimer’s disease

 goto top of outline Abstract

Background/Aims: Although most patients with frontotemporal dementia (FTD) present with neuropsychiatric symptoms, the frequency of psychotic symptoms is unclear. This study aims to determine the prevalence of psychotic symptoms in a large cohort of well-diagnosed and followed FTD patients compared to age-matched patients with Alzheimer’s disease (AD) and to further review the literature on psychosis in FTD. Methods: Delusions, hallucinations and paranoia were evaluated among 86 patients who met consensus criteria for FTD, had frontotemporal changes on functional neuroimaging and were followed for 2 years. They were compared to 23 patients with early-onset AD on a caregiver-administered psychiatric questionnaire. Results: Among the FTD patients, only 2 (2.3%) had delusions, 1 of whom had paranoid ideation; no FTD patient had hallucinations. This was significantly less than the AD patients, 4 (17.4%) of whom had delusions and paranoia. Other investigations fail to establish a significant association of psychosis with FTD. Conclusions: These findings, and a literature review, indicate that psychotic symptoms are rare in FTD, possibly due to limited temporal-limbic involvement in this disorder.

Copyright © 2008 S. Karger AG, Basel

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 goto top of outline Author Contacts

M.F. Mendez
Neurobehavior Unit (116AF; Bldg 500, 3S)
VA Greater Los Angeles Healthcare, 11301 Wilshire Blvd.
Los Angeles, CA 90073 (USA)
Tel. +1 310 478 3711, ext. 42696, Fax +1 310 268 4181, E-Mail

 goto top of outline Article Information

Accepted: November 19, 2007
Published online: January 17, 2008
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 1, Number of References : 49

 goto top of outline Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 25, No. 3, Year 2008 (Cover Date: March 2008)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (Print), eISSN: 1421–9824 (Online)

For additional information:

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