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Vol. 51, No. 6, 2007
Issue release date: February 2008
Section title: Original Paper
Ann Nutr Metab 2007;51:550–556
(DOI:10.1159/000114209)

Systematic Review of Fatty Acid Composition of Human Milk from Mothers of Preterm Compared to Full-Term Infants

Bokor S. · Koletzko B. · Decsi T.
aDepartment of Paediatrics, University of Pécs, Pécs, Hungary; bDr. von Hauner Children’s Hospital, University of Munich, Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/16/2006
Accepted: 7/19/2007
Published online: 1/28/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background: Fatty acid composition of human milk serves as guidance for the composition of infant formulae. The aim of the study was to systematically review data on the fatty acid composition of human milk of mothers of preterm compared to full-term infants. Methods: An electronic literature search was performed in English (Medline and Medscape) and German (SpringerLink) databases and via the Google utility. Fatty acid compositional data for preterm and full-term human milk were converted to differences between means and 95% confidence intervals. Results: We identified five relevant studies publishing direct comparison of fatty acid composition of preterm versus full-term human milk. There were no significant differences between the values of the principal saturated and monounsaturated fatty acids. In three independent studies covering three different time points of lactation, however, docosahexaenoic acid (DHA) values were significantly higher in milk of mothers of preterm as compared to those of full-term infants, with an extent of difference considered nutritionally relevant. Conclusion: Higher DHA values in preterm than in full-term human milk underlines the importance of using own mother’s milk for feeding preterm babies and raises the question whether DHA contents in preterm formulae should be higher than in formulae for full-term infants.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/16/2006
Accepted: 7/19/2007
Published online: 1/28/2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Koletzko B, Rodriguez-Palermo M: Polyunsaturated fatty acids in human milk and their role in early infant development. J Mammary Gland Biol Neoplasia 1999;3:269–284.

    External Resources

  2. Decsi T, Koletzko B: Role of long-chain polyunsaturated fatty acids in early human neurodevelopment. Nutr Neurosci 2000;3:293–306.
  3. Willatts P, Forsyth JS: The role of long-chain polyunsaturated fatty acids in infant cognitive development. Prostaglandins Leukot Essent Fatty Acids 2000;63:95–100.
  4. Morale SE, Hoffman DR, Castaneda YS, Wheaton DH, Burns RA, Birch EE: Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev 2005;81:197–203.
  5. Clandinin MT, Van Aerde JE, Merkel KL, Harris CL, Springer MA, Hansen JW, Diersen-Schade DA: Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. J Pediatr 2005;146:461–468.
  6. Fleith M, Clandinin MT: Dietary PUFA for preterm and term infants: review of clinical studies. Crit Rev Food Sci Nutr 2005;45:205–229.
  7. Aggett PJ, Haschke F, Heine W, Hernell O, Koletzko B, Launiala K, Rey J, Rubino A, Schöch G, et al: ESPGAN Committee on Nutrition: Committee report. Comment on the content and composition of lipids in infant formulas. Acta Paediatr Scand 1991;80:887–896.
  8. Hamosh M, Salem N Jr: Long-chain polyunsaturated fatty acids. Biol Neonate 1998;74:106–120.
  9. Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR, Chance GW: Extrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Hum Dev 1980;4:130–138.
  10. Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR, Chance GW: Intrauterine fatty acid accretion rates in human brain: Implications for fatty acid requirements. Early Hum Dev 1980;4:121–129.
  11. Jensen RG: Lipids in human milk. Lipids 1999;34:1243–1271.
  12. Hamosh M, Henderson TR, Kemper MA, et al: Long-chain polyunsaturated fatty acids (LC-PUFA) during early development: contribution of milk LC-PUFA to accretion rates varies among organs. Adv Exp Med Biol 2001;501:397–401.
  13. Bitman J, Wood DL, Hamosh M, Hamosh P, Metha NR: Comparison of the lipid composition of breast milk from mothers of term and preterm infants. Am J Clin Nutr 1983;38:300–312.
  14. Luukkainen P, Salo MK, Nikkai T: Changes in the fatty acid composition of preterm and term human milk from 1 week to 6 months of lactation. J Pediatr Gastroenterol Nutr 1994;18:355–360.
  15. Genzel-Boroviczény O, Wahle J, Koletzko B: Fatty acid composition of human milk during the first month after term and preterm delivery. Eur J Pediatr 1997;156:142–147.
  16. Rueda R, Ramírez M, García-Salmerón JL, Maldonado J, Gil A: Gestational age and origin of human milk influence total lipid and fatty acid contents. Ann Nutr Metab 1998;42:12–22.
  17. Kovács A, Funke S, Marosvölgyi T, Burus I, Decsi T: Fatty acids in early human milk after preterm and full-term delivery. J Pediatr Gastroenterol Nutr 2005;41:454–459.
  18. Jensen CL, Heird WC: Lipids with an emphasis on long-chain polyunsaturated fatty acids. Clin Perinatol 2002;29:261–281.
  19. Koletzko B, Thiel I, Abiodun PO: The fatty acid composition of human milk in Europe and Africa. J Pediatr 1992;120:62–70.
  20. Larqué E, Demmelmair H, Klinger M, De Jonge S, Bondy B, Koletzko B: In vivo investigation of the placental transfer of 13C-labeled fatty acids in humans. J Lipid Res 2003;44:49–55.
  21. Larqué E, Demmelmair H, Klinger M, De Jonge S, Bondy B, Koletzko B: Expression pattern of fatty acid transport protein-1 (FATP-1), FATP-4 and heart-fatty acid binding protein (H-FABP) Genes in human term placenta. Early Hum Dev 2006;82:697–701.
  22. Innis SM: Essential fatty acids in growth and development. Prog Lipid Res 1991;30:39–130.
  23. Innis SM: Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr 2003;143:1–8.

    External Resources

  24. Larque E, Demmelmair H, Koletzko B: Perinatal supply and metabolism of long-chain polyunsaturated fatty acids: importance for the early development of the nervous system. Ann NY Acad Sci 2002;967:299–310.
  25. Rocquelin G, Tapsoba S, Dop MC, et al: Lipid content and essential fatty acid (EFA) composition of mature Congolese breast milk are influenced by mothers’ nutritional status: impact on infants’ EFA supply. Eur J Clin Nutr 1998;52:164–171.
  26. Jensen RG: The Lipids of Human Milk. Boca Raton, CRC Press, 1989, pp 7–23.
  27. Koletzko B, Rodriguez-Palmero M: Polyunsaturated fatty acids in human milk and their role in early infant development. J Mammary Gland Biol Neoplasia 1999;4:269–284.
  28. Martin JC, Bougnoux P, Finon A, et al: Dependence of human milk essential fatty acids on adipose stores during lactation. Am J Clin Nutr 1993;58:653–659.
  29. Demmelmair H, Sauerwald T, Fidler N, et al: Polyunsaturated fatty acid metabolism during lactation. World Rev Nutr Diet. Basel, Karger, 2001, vol 88, pp 184–189.
  30. Del Prado M, Villalpando S, Elizando A, Rodriguez M, Demmelmair H, Koletzko B: Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low fat diet. Am J Clin Nutr 2001;74:242–247.