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Vol. 8, No. 1, 2008
Issue release date: April 2008
Section title: Original Paper
Pancreatology 2008;8:63–70
(DOI:10.1159/000114868)

A Prospective Cohort Study of Smoking in Acute Pancreatitis

Lindkvist B. · Appelros S. · Manjer J. · Berglund G. · Borgström A.
Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/16/2006
Accepted: 6/21/2007
Published online: 1/31/2008

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN

Abstract

Background/Aims: Little is known about risk factors for acute pancreatitis other than gallstones and alcohol consumption. The aim of this study was to investigate if smoking or body mass index (BMI) are associated with acute pancreatitis and to determine relative risks (RR) for acute pancreatitis related to smoking, BMI, and alcohol consumption. Methods: From 1974 to 1992, selected birth-year cohorts of residents in Malmö, Sweden (born 1921–1949) were invited to a health-screening investigation including physical examination, blood sampling and a questionnaire. In total, 33,346 individuals participated. Cases of acute pancreatitis were identified from diagnosis registries (n = 179). Incidence rates were calculated in different risk factor categories. A Cox’s analysis revealed RR. Results: Current versus never smoking at baseline was associated with acute pancreatitis (RR 2.14, 95% confidence interval (CI) 1.48–3.09) after adjustment for age, sex, BMI and alcohol consumption. This association was stronger in heavy smokers (20–30 cigarettes/day) (RR 3.19, 95% CI 2.03–5.00). Smoking was associated with a RR of 3.57 (95% CI 0.98–13.0) for acute pancreatitis in subjects who reported no alcohol consumption. An increased risk for acute pancreatitis was also found for high versus low risk, self-reported alcohol consumption (RR 2.55, 95% CI 1.59–4.08) and for γ-GT levels in the highest versus the lowest quartile (RR 2.14, 95% CI 1.32–3.49). There was also a weak correlation between BMI and acute pancreatitis. Conclusions: Smoking is associated with the incidence of acute pancreatitis in a dose-response manner.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/16/2006
Accepted: 6/21/2007
Published online: 1/31/2008

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 1424-3903 (Print)
eISSN: 1424-3911 (Online)

For additional information: http://www.karger.com/PAN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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