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Neuroepidemiology 2008;30:45–50

Anti-Inflammatory Agents and Cognitive Decline in a Bi-Racial Population

Grodstein F.a, c, f · Skarupski K.A.a, c · Bienias J.L.a, c · Wilson R.S.b, d, e · Bennett D.A.b, d · Evans D.A.a, c
aRush Institute for Healthy Aging, bRush Alzheimer’s Disease Center, Departments of cInternal Medicine, dNeurological Sciences, and ePsychology, Rush University Medical Center, Chicago, Ill., fChanning Lab, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass., USA
email Corresponding Author

 goto top of outline Key Words

  • Chicago Health and Aging Project
  • Nonsteroidal anti-inflammatory drugs
  • Cognitive function

 goto top of outline Abstract

In a prospective study among 4,409 subjects aged 65+ years, we assessed the relation of nonsteroidal anti-inflammatory agents (NSAIDs) to cognition. The main outcome was decline in global cognitive function, determined by average performance across four cognitive tests, over up to four interviews. We found similar rates of cognitive decline among recent users of aspirin and of other NSAIDs (largely ibuprofen) compared to those who did not use these NSAIDs. For lifetime duration of aspirin use, we failed to find an association with cognitive decline. However, for other NSAIDs, increasing duration of lifetime use was related to slower rates of cognitive decline, relative to no use of other NSAIDs (5+ years vs. no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.

Copyright © 2008 S. Karger AG, Basel

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 goto top of outline Author Contacts

Dr. Francine Grodstein
Channing Lab
181 Longwood Ave
Boston, MA 02115 (USA)
Tel. +1 617 525 2279, Fax +1 617 525 2008, E-Mail

 goto top of outline Article Information

Received: July 11, 2007
Accepted: November 21, 2007
Published online: February 7, 2008
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 19

 goto top of outline Publication Details


Vol. 30, No. 1, Year 2008 (Cover Date: March 2008)

Journal Editor: Feigin, V.L. (Auckland)
ISSN: 0251–5350 (Print), eISSN: 1423–0208 (Online)

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