Journal Mobile Options
Table of Contents
Vol. 146, No. 3, 2008
Issue release date: June 2008
Section title: Original Paper
Int Arch Allergy Immunol 2008;146:212–218
(DOI:10.1159/000115889)

A Single Oral Sensitization to Peanut without Adjuvant Leads to Anaphylaxis in Mice

Proust B. · Astier C. · Jacquenet S. · Ogier V. · Magueur E. · Roitel O. · Belcourt C. · Morisset M. · Moneret-Vautrin D.A. · Bihain B.E. · Kanny G.
aEA 3999 ‘Allergic Diseases: Diagnosis and Therapeutics’, Department of Internal Medicine, Clinical Immunology and Allergology, University Hospital, Central Hospital, Nancy, and bJE 2482 Lipidomix, Laboratory of Molecular Medicine and Therapeutics, Vandoeuvre-lès-Nancy, France

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/10/2007
Accepted: 10/22/2007
Published online: 2/11/2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: A model of peanut food allergy has been developed in mice using a simple sensitization protocol leading to a quantitatively measurable allergic response. Methods: C3H/HeJ mice received a single intragastric administration of whole peanut (80 mg) without adjuvant. Two weeks later, intraperitoneal challenge with peanut extract led to a severe anaphylaxis. Results: Anaphylactic reaction was evidenced by vascular leakage, severe clinical symptoms, a drop in body temperature, a decrease in breathing rate and also by increased concentrations of serum mouse mast cell protease-1. Sensitization to peanut was demonstrated by positive skin tests (ear swelling test and intradermal skin testing) and increased peanut-specific IgE levels. Conclusions: Thus, we obtained a model of severe peanut hypersensitivity within 2 weeks following single oral exposure without adjuvant. This model may be useful for further basic and applied studies on peanut allergy.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/10/2007
Accepted: 10/22/2007
Published online: 2/11/2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Kanny G, Moneret-Vautrin DA, Flabee J, Beaudouin E, Morisset M, Thévenin F: Population study of food allergy in France. J Allergy Clin Immunol 2001;108:133–140.
  2. Sicherer SH, Munoz-Furlong BA, Sampson HA: Prevalence of peanut and tree peanut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol 2003;112:1203–1207.
  3. Sampson HA: Update on food allergy. J Allergy Clin Immunol 2004;113:805–819.
  4. Joshi P, Mofidi S, Sicherer SH: Interpretation of commercial food ingredients labels parents of food-allergic children. J Allergy Clin Immunol 2002;109:1019–1021.
  5. Sampson HA, Mendelson L Rosen JP: Fatal and neo-fatal anaphylactic reactions to foods in children and adolescents. N Engl J Med 1992;327:380–384.
  6. Bock SA, Munoz-Furlong A, Sampson HA: Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001;107:193–197.

    External Resources

  7. Moneret-Vautrin DA, Morisset M, Flabbee J, Beaudouin E, Kanny G: Epidemiology of life-threatening and lethal anaphylaxis: a review. Allergy 2005;60:443–451.
  8. Crevel R: Industrial dimensions of food allergy. Proc Nutr Soc 2005;64:470–474.
  9. Li XM, Serebrisky D, Lee SY, Huang CK, Bardina L, Schofield BH, Stanley JS, Burks AW, Bannon GA, Sampson HA: A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol 2000;106:150–158.
  10. Morafo V, Srivastana K, Huang CK, Kleiner G, Lee SY, Sampson HA, Li AM: Genetic susceptibility to food allergy is linked to differential Th2-Th1 responses in C3H/HeJ and BALB/c mice. J Allergy Clin Immunol 2003;111:1122–1128.
  11. van Wijk F, Hartgring S, Koppelman SJ, Pieters R, Knippels LMJ: Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6 in an oral sensitization model. Clin Exp Allergy 2004;34:1422–1428.
  12. Adel-Patient K, Bernard H, Ah-Leung S, Créminon C, Wal JM: Peanut- and cow’s milk-specific IgE, Th2 cells and local anaphylactic reaction are induced in BALB/c mice orally sensitized with cholera toxin. Allergy 2005;60:658–664.
  13. Fischer R, McGhee JR, Lan Vu H, Atkinson P, Jackson RJ, Tomé D, Boyaka PN: Oral and nasal sensitization and lung reactivity in a mouse model of peanut allergy. Am J Pathol 2005;167:1621–1631.
  14. van Wijk F, Hoeks S, Nierkens S, Koppelman SJ, van Kooten P, Boon L, Knippels LMJ, Pieters R: CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. J Immunol 2005;174:174–179.
  15. Li XM, Zhang TF, Huang CK, Srivastana K, Teper AA, Zhang L, Schofield B, Sampson HA: Food allergy herbal formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol 2001;108:639–646.
  16. Lee SY, Huang CK, Zhang TF, Schofield BH, Burks AW, Bannon GA, Sampson HA: Oral administration of IL-12 suppresses anaphylactic reactions in a murine of model of peanut hypersensitivity. Clin Immunol 2001;101:220–228.
  17. Li XM, Srivastana K, Huleatt JW, Bottomly K, Burks AW, Sampson HA: Engineered recombinant peanut protein and heat killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model. J Immunol 2003;170:3289–3295.
  18. Srivastana KD, Kattan JD, Zou ZM, Li JH, Zhang L, Wallenstein S, Goldfarb J, Sampson HA, Li XM: The Chinese herbal medicine formula FAHF-2 completely blocks anaphylactic reactions in a murine model of peanut allergy. J Allergy Clin Immunol 2005;115:171–178.
  19. Astier C, Morisset M, Roitel O, Codreanu F, Jacquenet S, Franck P, Ogier, V, Petit N, Proust B, Moneret-Vautrin DA, Burks AW, Bihain B, Kanny G: Predictive value of skin prick-tests using recombinant allergens for diagnosis of peanut allergy. J Allergy Clin Immunol 2006;118:250–256.
  20. Vachon C, Savoie L: Circadian variation of food intake and digestive tract contents in the rat. Physiol Behav 1987;39:629–632.
  21. Sogawa H, Kubo C: Influence of short-term repeated fasting on the longevity of female (NZB x NZW) F1 mice. Mech Ageing Dev 2000;115:61–71.
  22. Li XM, Schofield BH, Huang CK, Kleiner GI, Sampson HA: A murine model of IgE-mediated cow’s milk hypersensitivity. J Allergy Clin Immunol 1999;103:206–214.
  23. von Garnier C, Astori M, Kettner A, Dufour N, Heusser C, Corradin G, Spertini F: Allergen-derived long peptide immunotherapy down-regulates specific IgE response and protects from anaphylaxis. Eur J Immunol 2000;30:1638–1645.
  24. Kimber I, Stone S, Dearman RJ: Assessment of the inherent allergenic potential of proteins in mice. Environ Health Perspect 2003;111:227–231.
  25. Clark AT, Ewan PW: Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance. Clin Exp Allergy 2003;33:1041–1045.
  26. Naito K, Hirama M, Okumura K, Ra C: Recombinant soluble form of the human high affinity receptor for IgE prevent anaphylactic shock in mice. J Allergy Clin Immunol 1996;97:773–780.
  27. Finkelman FD, Rothenberg ME, Brandt EB, Morris SC, Strait RT: Molecular mechanisms of anaphylaxis: lessons from studies with murine models. J Allergy Clin Immunol 2005;115:449–457.
  28. Shreffler WG, Beyer K, Chu TH, Burks AW, Sampson HA: Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 2004;113:776–782.