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Vol. 216, No. 4, 2008
Issue release date: May 2008
Section title: Clinical and Laboratory Investigations
Dermatology 2008;216:341–346
(DOI:10.1159/000116723)

Chronic Fatigue Syndrome after Human Parvovirus B19 Infection without Persistent Viremia

Seishima M. · Mizutani Y. · Shibuya Y. · Arakawa C.
Department of Dermatology, Ogaki Municipal Hospital, Ogaki City, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 8/20/2007
Accepted: 10/2/2007
Published online: 2/15/2008

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: It is unclear how often chronic fatigue syndrome (CFS) appears after human parvovirus B19 (B19) infection and whether prolonged B19 viremia or some other factors cause CFS. Objectives: To determine how often CFS appears after B19 infection and whether prolonged B19 DNA presence, antibody production and persistently reduced complement levels occur in CFS patients after B19 infection. Methods: Clinical findings were examined in 210 patients after B19 infection, and CH50, C3 and C4 levels were determined. B19 DNA and antibodies to B19 were also tested in 38 patients’ sera including 3 with CFS. Results: Serum B19 DNA disappeared after 4–5 months in all 18 patients tested. There are no differences in B19 DNA-positive period between patients with and without persistent symptoms. IgM antibody titers to B19 became reduced after 2 months in all 38 patients. Complement levels persistently decreased in a greater proportion of patients with persistent symptoms. Conclusions: The present study suggests that we should consider the possibility of CFS after B19 infection and that CFS may be derived from several aspects other than prolonged B19 DNA presence in sera.


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 8/20/2007
Accepted: 10/2/2007
Published online: 2/15/2008

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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