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Vol. 26, No. 2, 2008
Issue release date: April 2008

A History of Coeliac Disease

Losowsky M.S.
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Abstract

Coeliac disease may have an ancient history dating back to the 1st and 2nd centuries AD. The first clear description was given by Samuel Gee in 1888. He suggested that dietary treatment might be of benefit. In the early 20th century various diets were tried, with some success, but without clear recognition of the toxic components. The doctoral thesis of Wim Dicke of 1950 established that exclusion of wheat, rye and oats from the diet led to dramatic improvement. The toxicity was shown to be a protein component, referred to as gluten. Dicke’s colleagues, Weijers and Van de Kamer, showed that measurement of stool fat reflected the clinical condition. Early studies were in children but stool fat measurements documented that the condition could be recognised in adults. Histological abnormalities of the lining of the small intestine were demonstrated beyond doubt by Paulley in 1954 and techniques of per-oral biopsy described by Royer in 1955 and Shiner in 1956 afforded reliable diagnosis. Concurrence in monozygotic twins suggested a genetic component, confirmed by studies of HLA antigens. Additional, non-genetic factors seem likely. Circulating antibodies suggest an immunological mechanism of damage and provide non-invasive screening tests. Lymphoma, adenocarcinoma and ulceration of the small intestine and a range of immunological disorders are associated. A relationship with dermatitis herpetiformis was suggested by Samman in 1955 and established by Shuster and Marks in 1965 and 1968. The Coeliac Society (now Coeliac UK) was founded in 1968 and similar societies now exist across the world. They provide an extremely valuable service. Present problems include definition of the tolerated levels of gluten, whether oats are toxic for some or all coeliacs and the likelihood that the condition is relatively common and frequently without classical symptoms. Hope for the future is that more convenient methods of treatment will follow better understanding.



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References

  1. Roy K, Mao H-Q, et al: Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999;5:387–391.
  2. Lack G: Immunomodulation of food allergies; in Buttriss J (ed): Adverse Reactions to Food. Oxford, Blackwell Science, 2002, pp 165–169.
  3. Corazza GR, Andreani ML, et al: The smaller size of the ‘coeliac iceberg’ in adults. Scand J Gastroenterol 1997;32:917–919.
  4. Feighery C: Fortnightly review: Coeliac disease. BMJ 1999;319:236–239.
  5. Mäki M: Changing features of coeliac disease; in Mäki M, Collin P, Visakorpi JK (eds): Changing Features of Coeliac Disease. Tampere, The Finnish Coeliac Society, 1997, pp 1–7.
  6. Ascher H: The role of quantity and quality of gluten-containing cereals in the epidemiology of coeliac disease; in Mäki M, Collin P, Visakorpi JK (eds): Coeliac Disease. Tampere, Coeliac Disease Study Group, 1997, pp 15–22.
  7. Catassi C: Screening of coeliac disease; in Mäki M, Collin P, Visakorpi JK (eds): Coeliac Disease. Tampere, Coeliac Disease Study Group, 1996, pp 23–33.
  8. Bingley PJ, Williams AKJ, et al: Undiagnosed coeliac disease at age seven: population-based prospective birth cohort study. BMJ 2004;328:322–323.
  9. Fasano A, Berti I, et al: Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003;163:286–292.
  10. Corazza GR, Di Sario A, et al: Bone mass and metabolism in patients with coeliac disease. Gastroenterology 1995;109:122–128.
  11. Mazure R, Vazquez H, et al: Bone mineral affection in asymptomatic adult patients with celiac disease. Am J Gastroenterol 1994;89:2130–2134.
  12. Sher KS, Mayberry JF: Female fertility, obstetric and gynaecological history in coeliac disease: a case-control study. Acta Paediatr 1996;412(suppl):76–77.

    External Resources

  13. Corrao G, Corazza GR, et al: Serological screening of coeliac disease: choosing the optimal procedure according to various prevalence values. Gut 1994;35:771–775.
  14. Collin P, Reunala T, Mäki M: New diagnostic strategy for coeliac disease; in Mäki M, Collin P, Visakorpi JK (eds): Coeliac Disease. Tampere, Coeliac Disease Study Group, 1997, pp 47–51.
  15. Haboubi NY, Taylor S, Jones S: Coeliac disease and oats: a systematic review. Postgrad Med J 2006;82:672–678.
  16. Arentz-Hansen H, Fleckenstein B, et al: Molecular basis for oat intolerance in patients with coeliac disease. PloS Med 2004;1:84–92.
  17. Lundin KEA, Nilsen EM, et al: Oats induced villous atrophy in coeliac disease. Gut 2003;52:1649–1652.
  18. Janatuinen EK, Pikkararainen PH, et al: A comparison of diets with and without oats in adults with celiac disease. N Engl J Med 1995;333:1033–1037.
  19. Ellis HJ, Parnell NDJ, Ciclitira PJ: Cornflakes and coeliac disease. Gut 1998;42(suppl 1):A35.
  20. Faulkner-Hogg KB, Selby WS, Loblay RH: Dietary analysis in symptomatic patients with coeliac disease on a gluten-free diet: the role of trace amounts of gluten and non-gluten food intolerances. Scand J Gastroenterol 1999;34:784–789.
  21. Hischenhuber C, Crevel R, et al: Review article: safe amounts of gluten for patients with wheat allergy or coeliac disease. Aliment Pharmacol Ther 2006;23:559–575.
  22. Catassi C, Fabiani E, et al: A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr 2007;85:160–166.
  23. Ventura A, Magazzu G, Greco L: Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. Gastroenterology 1999;117:297–303.
  24. Hansen D, Brock-Jacobsen B, et al: Clinical benefit of a gluten-free diet in type 1 diabetic children with screening-detected celiac disease. Diabetes Care 2006;29:2452–2456.
  25. Collin P, Kaukinen K: Associated disorders in coeliac disease; in Lohiniemi S, Collin P, Mäki M (eds): Changing Features of Coeliac Disease. Tampere, The Finnish Coeliac Society, 1998, pp 89–91.
  26. Cooke WT, Holmes GKT: Coeliac Disease. Oxford, Churchill Livingstone, 1984.
  27. Bayless TM, Baer A, et al: Intestinal ulceration, flat mucosa and malabsorption: report of registry of 33 patients; in McNicholl B, et al (eds): Perspectives in Coeliac Disease. Lancaster, MTP Press, 1978, pp 311–3112.
  28. Neale G: A case of adult coeliac disease resistant to treatment. Br Med J 1968;2:678–684.
  29. Seliger G, Goldman AB, et al: Ulceration of the small intestine complicating celiac disease. Am J Dig Dis 1973;18:820–824.
  30. Scott BB: Studies in coeliac disease with particular reference to aetiology and pathogenesis; MD Thesis, University of London, 1975.
  31. Bayless TM, Kapelowitz RF, et al: Intestinal ulceration – a complication of celiac disease. N Engl J Med 1967;276:996–1002.
  32. Thaysen ThEH: Non-tropical sprue; in Milford H (ed): A Study in Idiopathic Steatorrhoea. London, Oxford University Press, 1932.
  33. Robertson DAF, Swinson CM, et al: Coeliac disease, splenic function, and malignancy. Gut 1982;23:666–669.
  34. Lewis HM, Reunala TL, et al: Protective effect of a gluten-free diet against development of lymphoma in dermatitis herpetiformis. Br J Dermatol 1996;135:363–367.
  35. Holmes GKT, Prior P, et al: Malignancy in coeliac disease – effect of a gluten-free diet. Gut 1989;30:333–338.
  36. Holmes GKT: Coeliac disease and malignancy; in Mäki et al (eds): Coeliac Disease. Tampere, Coeliac Disease Study Group, 1997, pp 81–90.
  37. Freeman HJ, Weinstein WM, et al: Primary abdominal lymphoma. Presenting manifestations of coeliac sprue, or complicating dermatitis herpetiformis. Am J Med 1977;63:358–394.

    External Resources

  38. Reunala TL, Leonard JN: Malignant disease in dermatitis herpetiformis. Clin Dermatol 1992;9:369–373.

    External Resources

  39. Swinson CM, Slavin G, et al: Coeliac disease and malignancy. Lancet 1983;1:111–115.
  40. Case Records of The Massachusetts General Hospital. N Engl J Med 1958;259:491–495.
  41. Harris OD, Cooke WT, et al: Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med 1967;42:899–912.
  42. Gough KR, Read AR, Naish JM: Intestinal reticulosis as a complication of idiopathic steatorrhoea. Gut 1962;3:232–239.
  43. Golden R: The small intestine and diarrhoea. Am J Roentgenol 1936;36:892–901.
  44. Gull W: Fatty stools from disease of the mesenteric glands. Guy’s Hosp Rep 1855;1:369–372.
  45. Reunala T, Mäki M: Dermatitis herpetiformis; a genetic disease. Eur J Dermatol 1993;3:519–526.
  46. Brow JR, Parker F, et al: The small intestinal mucosa in dermatitis herpetiformis. Gastroenterology 1971;60:355–361.
  47. Shuster S, Watson AJ, Marks J: Coeliac syndrome in dermatitis herpetiformis. Lancet 1968;1:1101–1106.
  48. Shuster S, Marks J: Dermatogenic enteropathy. Lancet 1965;1:1367–1368.

    External Resources

  49. Samman PD: Idiopathic steatorrhoea. Proc R Soc Med 1955;48:774–775.
  50. Van Heel DA, West J: Recent advances in coeliac disease. Gut 2006;55:1037–1046.
  51. Schuppan D: Current concepts of celiac disease pathogenesis. Gastroenterology 2000;119:234–242.
  52. Anwar R, Stewart AD, et al: Molecular basis of inherited factor XIII deficiency: identification of multiple mutations provides insights into protein function. Br J Haematol 1995;91:728–735.
  53. Board PG, Losowsky MS, Miloszewski KJA: Factor XIII: inherited and acquired deficiency. Blood Rev 1993;7:229–242.
  54. Greenberg CS, Birckbichler PJ, Rice RH: Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues. FASEB J 1991;5:3071–3077.
  55. Maiuri L, Ciacci C, et al: Unexpected role of surface transglutaminase type II in celiac disease. Gastroenterology 2005;129:1400–1413.
  56. Reif S, Lerner A: Tissue transglutaminase – the key player in celiac disease: a review. Autoimmun Rev 2004;3:40–45.
  57. Vader LW, de Ru A, et al: Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J Exp Med 2002;195:643–649.
  58. Shan L, Molberg Ø, et al: Structural basis for gluten intolerance in celiac sprue. Science 2002;297:2275–2279.
  59. Esposito C, Paparo F, et al: Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease. Am J Gastroenterol 2003;98:1813–1820.
  60. Howdle PD, Losowsky MS: Coeliac disease in adults; Marsh MN (ed): Coeliac Disease. London, Blackwell Scientific, 1992, pp 49–80.
  61. Sollid LM, Scott H: New tool to predict celiac disease on its way to the clinics. Gastroenterology 1998;115:1584–1594.
  62. Sulkanen S, Halttunen T, et al: Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology 1998;115:1322–1328.
  63. Dieterich W, Eberhardt L, et al: Autoantibodies to tissue transglutiminase as predictors of celiac disease. Gastroenterology 1998;115:1317–1321.
  64. Weitz JC, Montalva R, et al: Anti-transglutaminase antibodies determination for the diagnosis of celiac disease. Rev Med Childh 2003;131:31–36.
  65. Dieterich W, Ehnis T, et al: Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997;3:797–801.
  66. Hobbs JR, Hepner GW: Deficiency of gamma M-globulin in coeliac disease. Lancet 1968;1:217–220.
  67. Hälström O: Comparison of IgA-class reticulin and endomysium antibodies in coeliac disease and dermatitis herpetiformis. Gut 1989;30:1225–1232.
  68. Chorzelski TP, Sulej J, et al: IgA class endomysium antibodies in dermatitis herpetiformis and celiac disease. Ann NY Acad Sci 1983;420:325–334.
  69. Seah PP, Fry L, Hoffbrand AV, Holborow EJ: Tissue antibodies in dermatitis herpetiformis and adult coeliac disease. Lancet 1971;1:834–836.
  70. Rubin W, Fauci AS, Sleisenger MN, Jeffries GH: Immunofluorescent studies in adult celiac disease. J Clin Invest 1965;44:475–485.
  71. Taylor KB, Thomson DL, et al: An immunological study of coeliac disease and idiopathic steatorrhoea. Br Med J 1961;2:1727–1731.
  72. Berger E: Allergic pathogenesis of celiac disease with studies of the splitting up of pathogenic antigens by enzymes (in German). Bibl Paediatr 1958;67:1–55.
  73. Bourgey M, Calcagno G, Tinto N, et al: HLA-related genetic risk for coeliac disease. Gut 2007;56:1054–1059.
  74. Partanen J: Major histocompatibility complex and coeliac disease; in Mäki M, Collin P, Visakorpi JK (eds): Coeliac Disease. Tampere, Coeliac Disease Study Group, 1997, pp 253–264.
  75. Brett PM, Yiannakou JY, Morris MA, et al: Common HLA alleles, rather than rare mutants, confer susceptibility to coeliac disease. Ann Hum Genet 1999;63:217–225.
  76. Stokes PL, Asquith P, et al: Histocompatibility antigens associated with adult coeliac disease. Lancet 1972;2:162–164.
  77. Falchuk ZM, Rogentine GN, Strober W: Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy. J Clin Invest 1972;51:1602–1605.
  78. Ellis J: Coeliac disease and other gluten-sensitive disorders; in Buttriss J (ed): Adverse Reactions to Food. London, Blackwell Science, 2002, pp 112–130.
  79. Mäki M, Koskimies S, Visakorpi JK: Latent coeliac disease; in Kumar PJ, Walker-Smith JA (eds): Coeliac Disease: One Hundred Years. London, St Bartholomew’s Hospital, 1988, p 245.
  80. McConnell RB, Whitwell F: Small-intestinal histology in coeliac disease. Lancet 1975;2:418.
  81. Weinstein WM: Latent celiac sprue. Gastroenterology 1974;66:489–493.
  82. Howdle PD, Corazza GR, et al: In vitro diagnosis of coeliac disease – an assessment. Gut 1981;22:939–947.
  83. Browning RH, Trier JS: Organ culture of mucosal biopsies in human small intestine. J Clin Invest 1969;48:1423–1432.
  84. Losowsky MS, Walker BE, Kelleher J: Malabsorption in Clinical Practice. Oxford, Churchill Livingstone, 1974.
  85. Flick AL, Quinton WE, Rubin CE: A peroral hydraulic biopsy tube for multiple sampling at any level of the gastrointestinal tract. Gastroenterology 1961;40:120–126.
  86. Crosby WH, Kugler HW: Intraluminal biopsy of the small intestine: The intestinal biopsy capsule. Am J Dig Dis 1957;2:236–241.
  87. Shiner M: Duodenal biopsy. Lancet 1956;1:17–19.
  88. Royer M, Croxatto O, et al: Biopsia duodenal por aspiración bajo control radioscópico. Prensa Med Argent 1955;42:2515–2519.
  89. Paulley JW: Observations on the aetiology of idiopathic steatorrhoea. Br Med J 1954;2:1318–1321.
  90. Corazza GR, Frisoni M, Valentini R, et al: Jacomo Bartolomeo Beccari and the discovery of gluten; in Kumar PJ, Walker-Smith JA (eds): Coeliac Disease: One Hundred Years. London, St Bartholomew’s Hospital, 1988, pp 11–14.
  91. French JM, Hawkins CF, Smith N: The effect of a wheat-gluten free diet in adult idiopathic steatorrhoea – a study of 22 cases. Quart J Med 1957;26:481–499.
  92. Dicke WK, Weijers HA, van de Kamer JH: Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr Stockh 1953;42:34–42.
  93. Dawson AM, Kumar P: Coeliac disease; in Booth CC, Neale G (eds): Disorders of the Small Intestine. London, Blackwell Scientific, 1985, p 153–178.
  94. Anderson CM: The evolution of a successful treatment of coeliac disease; in Marsh MN (ed): Coeliac Disease. London, Blackwell Scientific, 1992, p 1–16.
  95. Gee SJ: The coeliac affection. St Bartholomew’s Hosp Rep 1888;24:17–20.
  96. Adams F: Extant Works of Aretaeus the Cappadocian. London, The Sydenham Society, 1856.


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