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Depressive Symptoms, Vascular Risk Factors and Mild Cognitive Impairment

The Italian Longitudinal Study on Aging Panza F.a · D’Introno A.a · Colacicco A.M.a · Capurso C.c · Del Parigi A.h · Caselli R.J.i · Todarello O.b · Pellicani V.b · Santamato A.d · Scapicchio P.e · Maggi S.g · Scafato E.f · Gandin C.f · Capurso A.a · Solfrizzi V.a
aDepartment of Geriatrics, Center for Aging Brain, Memory Unit, and bDepartment of Neurological and Psychiatric Sciences, University of Bari, Bari, Departments of cGeriatrics and dPhysical Medicine and Rehabilitation, University of Foggia, Foggia, eCatholic University of the Sacred Heart and fNational Center for Epidemiology, Surveillance and Health Promotion – CNESPS, Istituto Superiore di Sanità, Rome, and gNational Research Council of Italy, CNR, Center on Aging, Padua, Italy; hNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Ariz., and iDepartment of Neurology, Mayo Clinic, Scottsdale, Ariz., USA Dement Geriatr Cogn Disord 2008;25:336–346 (DOI:10.1159/000119522)


Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65- to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85–1.84, χ2 = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI.


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