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Neuroanatomical Correlates of Unawareness of Memory Deficits in Early Alzheimer’s Disease

Hanyu H.a · Sato T.a · Akai T.a · Shimizu S.a · Hirao K.a · Kanetaka H.a · Iwamoto T.a · Koizumi K.b
Departments of aGeriatric Medicine and bRadiology, Tokyo Medical University, Tokyo, Japan Dement Geriatr Cogn Disord 2008;25:347–353 (DOI:10.1159/000119594)


Background/Aims: To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer’s disease (AD). Methods: We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method. Results: Statistical maps demonstrated a more extensive and severe reduction in perfusion in the unaware group than in the aware group. Quantitative analysis demonstrated a significant difference between the groups in the right subcallosal, anterior cingulate and cingulate gyri and left orbital, subcallosal, and anterior cingulate gyri. Conclusion: Functional damage to the inferior, medial and orbital frontal lobes as well as the anterior cingulate gyri may be associated with the lack of awareness in patients with early AD.


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