Journal Mobile Options
Table of Contents
Vol. 25, No. 4, 2008
Issue release date: April 2008

Neuroanatomical Correlates of Unawareness of Memory Deficits in Early Alzheimer’s Disease

Hanyu H. · Sato T. · Akai T. · Shimizu S. · Hirao K. · Kanetaka H. · Iwamoto T. · Koizumi K.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

Background/Aims: To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer’s disease (AD). Methods: We compared regional perfusion deficits between AD patients with awareness (n = 19) and unawareness (n = 19). SPECT data were analyzed by statistical brain imaging method. Results: Statistical maps demonstrated a more extensive and severe reduction in perfusion in the unaware group than in the aware group. Quantitative analysis demonstrated a significant difference between the groups in the right subcallosal, anterior cingulate and cingulate gyri and left orbital, subcallosal, and anterior cingulate gyri. Conclusion: Functional damage to the inferior, medial and orbital frontal lobes as well as the anterior cingulate gyri may be associated with the lack of awareness in patients with early AD.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Ecklund-Johnson E, Torres I: Unawareness of deficits in Alzheimer’s disease and other dementias: operational definitions and empirical findings. Neuropsychol Rev 2005;15:147–166.
  2. Albert SM, Michaels K, Padilla M, Pelton G, Bell K, Marder K, Stern Y, Devanmand DP: Functional significance of mild cognitive impairment in elderly patients without a dementia diagnosis. Am J Geriatr Psychiatry 1999;7:213–220.
  3. Tabert MH, Albert SM, Borukhova-Milov L, Camacho Y, Pelton G, Liu X, Stern Y, Devanand DP: Functional deficits in patients with mild cognitive impairment. Prediction of AD. Neurology 2002;58:758–764.
  4. Vogel A, Stokholm J, Gade A, Andersen BB, Hejl A-M, Waldemar G: Awareness of deficits in mild cognitive impairment and Alzheimer’s disease: do MCI patients have impaired insight? Dement Geriatr Cogn Disord 2004;17:181–187.
  5. Harwood DG, Sultzer DL, Feil D, Monserratt L, Freedman E, Mandelkern MA: Frontal lobe hypometabolism and impaired insight in Alzheimer disease. Am J Geriatr Psychiatry 2005;13:934–941.
  6. Salmon E, Perani D, Herholz K, Marique P, Kalbe E, Hotthoff V, Delbeuck X, Beuthien-Baumann B, Pelati O, Lespagnard S, Collette F, Garraux G: Neural correlates of anosognosia for cognitive impairment in Alzheimer’s disease. Hum Brain Mapp 2006;27:588–597.
  7. Reed BR, Jagust WJ, Coulter L: Anosognosia in Alzheimer’s disease: relationship to depression, cognitive function, and cerebral perfusion. J Clin Exp Neuropsychol 1993;15:231–244.
  8. Starkstein SE, Vazquez S, Migliorelli R, Teson A, Sabe L, Leiguarda R: A single-photon emission computed tomographic study of anosognosia in Alzheimer’s disease. Arch Neurol 1995;52:415–420.
  9. Derouesne C, Thibault S, Lagha-Pierucci S, Baudouin-Madec V: Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type. Int J Geriatr Psychiatry 1999;14:1019–1030.
  10. Vogel A, Hasselbalch SG, Gade A, Ziebell M, Waldemar G: Cognitive and functional neuroimaging correlates for anosognosia in mild cognitive impairment and Alzheimer’s disease. Int J Geriatr Psychiatry 2005;20:238–246.
  11. Mimura M, Yano M: Memory impairment and awareness of memory deficits in early-stage Alzheimer’s disease. Rev Neurosci 2006;17:253–266.
  12. McKhann G, Drachman D, Folstein M, Katzman R, PriceD, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health anf Human Services Task Force on Alzheimer’s disease. Neurology 1984;34:939–944.
  13. Folstein MF, Folstein SE, McHugh PR: ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
  14. Highes CP, Berg L, Danzieger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566–572.

    External Resources

  15. Wechsler DA: WMS-R Manual. New York, Psychological Corporation, 1987.
  16. Rosen WG, Mohs RC, Davis KL: A new rating scale for Alzheimer’s disease. Am J Psychiatry 1984;141:1356–1364.
  17. Sheikh JI, Yesavage JA: Geriatric depression scale (GDS), recent evidence and development of a shorter version. Clin Gerontol 1986;5:165–173.

    External Resources

  18. Wilson B, Cockburn J, Baddeley A, Hiorns R: The development and validation of a test battery for detecting and monitoring everyday memory problems. J Clin Exp Neuropsychol 1989;11:855–870.
  19. Kazui H, Watamori TS, Honda R, Mori E: The validation of a Japanese version of the Everyday Memory Checklist (in Japanese). No To Shinkei 2003;55:317–325.

    External Resources

  20. Kazui H, Hirono N, Hashimoto M, Nakano Y, Matsumoto K, Takatsuki Y, Mori E, Ikejiri Y, Takeda M: Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer’s disease. J Geriatr Psychiatry Neurol 2006;19:3–12.
  21. Hanyu H, Sato T, Akai T, Sakai M, Takasaki R, Iwamoto T: Awareness of memory deficits in patients with dementias: a study with the Everyday Memory Checklist (in Japanese). Nippon Ronen Igakukai Zasshi 2007:44:463–469.
  22. Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE: A diagnostic approach in Alzheimer’s disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med 1995;36:1238–1248.
  23. Talairach J, Tournoux P: Co-Planar Stereotactic Atlas of the Human Brain. New York, Thieme, 1998.
  24. Minoshima S, Koeppe RA, Frey KA, Kuhl DE: Anatomic standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med 1994;35:1528–1537.
  25. Mizumura S, Kumita S, Cho K, Ishihara M, Nakajo H, Toba M, Kumazaki T: Development of quantitative analysis method for stereotactic brain image: Assessment of reduced accumulation in extent and severity using anatomical segmentation. Ann Nucl Med 2003;17:289–295.
  26. Ott BR, Noto RB, Fogel BS: Apathy and loss of insight in Alzheimer’s disease: a SPECT imaging study. J Neuropsychiatr Clin Neurosci 1996;8:41–46.
  27. Michon A, Deweer B, Pillon B, Dubois B: Relation of anosognosia to frontal lobe dysfunction in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 1994;57:805–809.
  28. Mangone CA, Hier DB, Gorelick PB, Ganellen RJ, Langenberg P, Boarman R, Dollear WC: Impaired insight in Alzheimer’s disease. J Geriatr Psychiatry Neurol 1991;4:189–193.
  29. Ott BR, Lafleche G, Whelihan WM, Buongiorno GW, Albert MS, Fogel BS: Impaired awareness of deficits in Alzheimer’s disease. Alzheimer Dis Assoc Disord 1996;10:68–76.
  30. Carter CS, Braver TS, Barch DM, Botvinick MM, Noll D, Cohen JD: Anterior cingulated cortex, error detection, and online monitoring of performance. Science 1998;280:747–749.
  31. O’Connell RG, Dockree PM, Bellgrove MA, Kelly SP, Hester R, Garavan H, Robertson IH, Foxe JJ: The role of cingulate cortex in the detection of errors with and without awareness: a high-density electrical mapping study. Eur J Neurosci 2007;25:2571–2579.
  32. Klein TA, Endrass T, Kathmann N, Neumann J, Yves von Cramon D, Ullsperger M: Neural correlates of error awareness. Neuroimage 2007;34:1774–1781.
  33. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatry Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308–2314.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50