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Vol. 30, No. 2, 2008
Issue release date: April 2008
Section title: Original Paper
Neuroepidemiology 2008;30:105–111
(DOI:10.1159/000120023)

Incidence and Prevalence of Amyotrophic Lateral Sclerosis in Uruguay: A Population-Based Study

Vázquez M.C. · Ketzoián C. · Legnani C. · Rega I. · Sánchez N. · Perna A. · Penela M. · Aguirrezábal X. · Druet-Cabanac M. · Medici M.
aInstituto de Neurología, Hospital de Clínicas, Facultad de Medicina, Universidad de la Republica, bHospital de Clínicas, Montevideo, Uruguay; cInstitute of Neurological Epidemiology and Tropical Neurology, Faculty of Medicine, Limoges, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/1/2007
Accepted: 12/31/2007
Published online: 3/11/2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

Objective: To determine the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in the Republic of Uruguay.Methods: The study was performed in Uruguay (3,241,003 inhabitants) during a 2-year period (2002–2003). To ensure complete case ascertainment, multiple sources of information were used, including all the neurologists, other medical specialties, general physicians, neurophysiology laboratories, hospital medical records and death certificates. ALS diagnosis was based on El Escorial criteria. Although all patients with motor neuron disease were enrolled in the follow-up, only probable and definite cases are included in the study. Results: Between January 1st, 2002, and December 31st, 2003, 89 new patients were diagnosed with probable or definite ALS. The mean annual incidence rate was 1.37 per 100,000 persons. The incidence was higher for men (1.95) than for women (0.84) with a male to female ratio of 2:1. For both, the incidence increased throughout the years showing a peak in the 65–74 age group among men and the 55–64 age group among women. Mean age at onset of ALS disease was 58.7 years. The estimated mean annual incidence for ALS calculated by the capture recapture method was 1.42 (95% CI, 1.13–1.72). On December 31st, 2002, the crude prevalence was 1.9 per 100,000 inhabitants. Conclusions: ALS incidence is within a narrow range across countries despite the genetic, environmental and socioeconomic differences when similar prospective design, diagnosis criteria and data analyses are applied.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/1/2007
Accepted: 12/31/2007
Published online: 3/11/2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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