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Table of Contents
Vol. 217, No. 1, 2008
Issue release date: June 2008
Section title: Clinical and Laboratory Studies
Dermatology 2008;217:38–44
(DOI:10.1159/000121473)

Melanoma Markers in Marathon Runners: Increase with Sun Exposure and Physical Strain

Richtig E. · Ambros-Rudolph C.M. · Trapp M. · Lackner H.K. · Hofmann-Wellenhof R. · Kerl H. · Schwaberger G.
aDepartment of Dermatology and bInstitute of Physiology, Medical University of Graz, and cInstitute of Medical Engineering, Graz University of Technology, Graz, Austria

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Studies

Received: 6/25/2007
Accepted: 10/26/2007
Published online: 3/27/2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Marathon runners seem to have an increased melanoma risk. Objective: To identify potential melanoma markers. Methods: 150 marathon runners volunteered to take part in the skin cancer screening campaign. After the runners completed a questionnaire about melanoma risk factors, types of sportswear and training programs, they received a total skin examination. The number of lentigines and nevi on the left shoulder and the left buttock were counted in each participant using templates in standardized positions. The potential association of training sportswear and training parameters with the number of lentigines and nevi on the left shoulder was evaluated. Results: The mean number of lentigines on the left shoulder was 19.6 ± 18.2 (SD), whereas no lentigines were found on the left buttock (p = 0.000). The number of nevi also differed significantly between the 2 localizations with higher numbers on the left shoulder (p = 0.000). While lifetime sunburn history and type of sportswear correlated with the number of lentigines, training parameters had an impact on the number of nevi. Independent of their mean weekly running time, runners with higher heart rates while training, higher training velocities and higher physical strain indexes showed more nevi on the shoulder than the other runners (p = 0.029, 0.046, 0.038, respectively). Conclusion: Sun exposure and high physical strain lead to an increase in melanoma markers such as lentigines and nevi in marathon runners.


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Studies

Received: 6/25/2007
Accepted: 10/26/2007
Published online: 3/27/2008

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Heymann WR: Dermatologic problems of the endurance athlete. J Am Acad Dermatol 2005;52:345–346.
  2. Almond CS, Shin AY, Fortescue EB, Mannix RC, Wypij D, Binstadt BA, Duncan CN, Olson DP, Salerno AE, Newburger JW, Greenes DS: Hyponatremia among runners in the Boston marathon. N Engl J Med 2005;352:1550–1556.
  3. Goudie AM, Tunstall-Pedoe DS, Kerins M: Altered mental status after a marathon. N Engl J Med 2005;352:1613–1614.
  4. Ambros-Rudolph CM, Hofmann-Wellenhof R, Richtig E, Müller-Fürstner M, Soyer HP, Kerl H: Malignant melanoma in marathon runners. Arch Dermatol 2006;142:1471–1474.
  5. Lakier Smith L: Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med 2003;33:347–364.
  6. Suzuki K, Yamada M, Kurakake S, Okamura M, Yamaya K, Liu Q, Kudoh S, Kowatari K, Nakaji S, Sugawara K: Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans. Eur J Appl Physiol 2000;81:281–287.
  7. Fitzpatrick TB: The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 1988;124:869–871.
  8. Garbe C, Buttner P, Weiss J, Soyer HP, Stocker U, Kruger S, Roser M, Weckbecker J, Panizzon R, Bahmer F, et al: Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi, and actinic lentigines: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society. J Invest Dermatol 1994;102:700–705.
  9. Bauer J, Garbe C: Acquired melanocytic nevi as risk factor for melanoma development: a comprehensive review of epidemiological data. Pigment Cell Res 2003;16:297–306.
  10. Gandini S, Sera F, Cattaruzza MS, Pasquini P, Abeni D, Boyle P, Melchi CF: Meta-analysis of risk factors for cutaneous melanoma. I. Common and atypical nevi. Eur J Cancer 2005;41:28–44.
  11. Garbe C, Buttner P, Weiss J, Soyer HP, Stocker U, Kruger S, Roser M, Weckbecker J, Panizzon R, Bahmer F, et al: Risk factors for developing cutaneous melanoma and criteria for identifying persons at risk: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society. J Invest Dermatol 1994;102:695–699.
  12. Kefford RF, Mann GJ, Bishop JN: Genetic predisposition to melanoma; in Thompson JF, Morton DL, Kroon BBR (eds): Textbook of Melanoma. London, Dunitz, 2004, pp 56–64.
  13. Reguiaï Z, Jovenin N, Bernard P, Derancourt C: Melanoma, past severe sunburns and multiple solar lentigines of the upper back and shoulders. Dermatology 2008;216:330–336.
  14. Derancourt C, Bourdon-Lanoy E, Grob JJ, Guillaume JC, Bernard P, Bastuji-Garin S: Multiple large solar lentigos on the upper back as clinical markers of past severe sunburn: a case-control study. Dermatology 2007;214:25–31.
  15. Gandini S, Sera F, Cattaruzza MS, Pasquini P, Picconi O, Boyle P, Melchi CF: Meta-analysis of risk factors for cutaneous melanoma. II. Sun exposure. Eur J Cancer 2005;41:28–44.
  16. Armstrong B: Epidemiology of cutaneous melanoma and current trends; in Thompson JF, Morton DL, Kroon BBR (eds): Textbook of Melanoma. London, Dunitz, 2004, pp 65–80.
  17. Dore JF, Boniol M: Environment influences on cutaneous melanoma; in Thompson JF, Morton DL, Kroon BBR (eds): Textbook of Melanoma. London, Dunitz, 2004, pp 43–55.
  18. Bastiaens M, Hoefnagel J, Westendorp R, Vermeer BJ, Bouwes Bavinck JN: Solar lentigines are strongly related to sun exposure in contrast to ephelides. Pigment Cell Res 2004;17:225–229.
  19. Mailler-Savage EA, Adams BB: Skin manifestations of running. J Am Acad Dermatol 2006;55:290–301.
  20. Möhrle M, Heinrich L, Schmid A, Garbe C: Extreme UV exposure of professional cyclists. Dermatology 2000;201:44–45.
  21. Möhrle M, Garbe C: Does mountaineering increase the incidence of cutaneous melanoma. Dermatology 1999;199:201–203.
  22. Möhrle M: Ultraviolet exposure in the Ironman triathlon. Med Sci Sports Exerc 2001;33:1385–1386.
  23. Adams BB: Dermatologic disorders of the athlete. Sports Med 2002;32:309–321.
  24. Moehrle M, Koehle W, Dietz K, Lischka G: Reduction of minimal erythema dose by sweating. Photodermatol Photoimmunol Photomed 2000;16:260–262.
  25. Hollenbeak CS, Todd MM, Billingsley EM, Harper G, Dyer AM, Lengerich EJ: Increased incidence of melanoma in renal transplant recipients. Cancer 2005;104:1962–1967.
  26. Hallal PC, Victora CG, Azevedo MR, Wells JC: Adolescent physical activity and health: a systematic review. Sports Med 2006;36:1019–1030.
  27. Scharhag J, Meyer T, Gabriel HHW, Schlick B, Faude O, Kindermann W: Does prolonged cycling of moderate intensity affect immune cell function? Br J Sports Med 2005;39:171–177.