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Vol. 77, No. 2, 2008
Issue release date: April 2008
Digestion 2008;77:87–91
(DOI:10.1159/000122228)

Extract of Radix Curcumae Prevents Gastric Cancer in Rats

Lu B. · Xu L. · Yu L. · Zhang L.
Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

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Abstract

Objective: Radix curcumae is a Chinese medicinal herb commonly used in the treatment of malignancy. This study was to investigate the chemopreventive effect of an extract solution from radix curcumae in a rat model of gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Methods: Eighty male Wistar rats were randomly allocated to 5 groups administered different agents for 40 weeks: group A, water and normal saline; group B, MNNG and normal saline; group C, MNNG and celecoxib; group D, MNNG and low-dose (1 g/ml) radix curcumae steam distillation extract solution; group E, MNNG and high-dose (2 g/ml) radix curcumae wet distillation extract solution. At the end of week 40, all rats alive were sacrificed. Gastric cancer and precancerous lesions in the stomach were evaluated by histology. Results: In total there were 35 deaths during the study period. The incidences of gastric cancer were 0.0% (0/16) in group A, 44.4% (7/16) in group B, 12.5% (2/16) in group C, 12.5% (2/16) in group D and 12.5% (2/16) in group E. Tumor incidence and tumor volume were significantly lower in groups C, D and E compared to those in group B (p < 0.05). There was no significant difference of tumor incidence and tumor volume among groups C, D and E (p = 1.000). Conclusion: Extract solution from radix curcumae obtained by the steam distillation procedure has a chemopreventive effect on gastric cancer induced by MNNG in rats.



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