Previously, we performed an MRI study that revealed smaller volumes of the subregions of the cerebellar vermis in men and women with chronic schizophrenia. An issue that arose from that study was whether similar structural changes in the cerebellum are found in patients with first-episode schizophrenia. In the present study, MRI scans were acquired from 14 drug-naive patients with first-episode schizophrenia and 16 healthy subjects, and used to measure the volumes of their cerebellar subregions. Positive symptom, negative symptom and cognitive cluster scores were attained using the Positive and Negative Syndrome Scale. Patients with first-episode schizophrenia had reduced volumes of the anterior vermis and posterior superior vermis compared with healthy subjects. We confirmed that there was a volume reduction of the cerebellar vermis in drug-naive patients with first-episode schizophrenia. Smaller volumes of the posterior superior vermis were associated with worse cognitive cluster scores in patients with first-episode schizophrenia.
© 2008 S. Karger AG, Basel
- Vermis, cerebellar
- Cognitive cluster scores
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Gaku Okugawa, MD, PhD
Department of Neuropsychiatry, Kansai Medical University
2-3-1 Shinmachi Hirakata
Osaka 573-1191 (Japan)
Tel. +81 72 804 0101, Fax +81 72 804 0166, E-Mail email@example.com
Received: August 5, 2007
Accepted after revision: January 22, 2008
Published online: April 2, 2008
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 1, Number of References : 23
Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Vol. 56, No. 4, Year 2007 (Cover Date: April 2008)
Journal Editor: Strik W. (Bern)
ISSN: 0302–282X (Print), eISSN: 1423–0224 (Online)
For additional information: http://www.karger.com/NPS
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