Background/Aim: Harmane [1-methyl-9H-pyrido(3,4-b)indole] is a tremor-producing neurotoxin. Blood harmane concentrations are elevated in essential tremor (ET) patients for unclear reasons. Potential mechanisms include increased dietary harmane intake (especially through well-cooked meat) or genetic-metabolic factors. We tested the hypothesis that meat consumption and level of meat doneness are higher in ET cases than in controls. Methods: Detailed data were collected using the Lawrence Livermore National Laboratory Meat Questionnaire. Results: Total current meat consumption was greater in men with than without ET (135.3 ± 71.1 vs. 110.6 ± 80.4 g/day, p = 0.03) but not in women with versus without ET (80.6 ± 50.0 vs. 79.3 ± 51.0 g/day, p = 0.76). In an adjusted logistic regression analysis in males, higher total current meat consumption was associated with ET (OR = 1.006, p = 0.04, i.e., with 10 additional g/day of meat, odds of ET increased by 6%). Male cases had higher odds of being in the highest than lowest quartile of total current meat consumption (adjusted OR = 21.36, p = 0.001). Meat doneness level was similar in cases and controls. Conclusion: This study provides evidence of a dietary difference between male ET cases and male controls. The etiological ramifications of these results warrant additional investigation.
© 2008 S. Karger AG, Basel
- Dietary epidemiology, essential tremor
- Essential tremor
- Diet, tremor
- Metabolism, meat
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Dr. Elan Louis
Unit 198, Neurological Institute
710 West 168th Street
New York, NY 10032 (USA)
Tel. +1 212 305 9194, Fax +1 212 305 1304, E-Mail email@example.com
Received: September 26, 2007
Accepted: January 23, 2008
Published online: April 2, 2008
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 26
Vol. 30, No. 3, Year 2008 (Cover Date: May 2008)
Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251–5350 (Print), eISSN: 1423–0208 (Online)
For additional information: http://www.karger.com/NED
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