Vol. 30, No. 3, 2008
Issue release date: May 2008
Free Access
Neuroepidemiology 2008;30:161–166
Original Paper
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Dietary Epidemiology of Essential Tremor: Meat Consumption and Meat Cooking Practices

Louis E.D.a-d · Keating G.A.e · Bogen K.T.e · Rios E.a · Pellegrino K.M.a · Factor-Litvak P.d
aG.H. Sergievsky Center, bDepartment of Neurology, and cTaub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, and dDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, N.Y., eEnergy and Environmental Directorate, Lawrence Livermore National Security, LLC, Livermore, Calif., USA
email Corresponding Author

 goto top of outline Key Words

  • Dietary epidemiology, essential tremor
  • Essential tremor
  • Toxin
  • Harmane
  • Diet, tremor
  • Metabolism, meat

 goto top of outline Abstract

Background/Aim: Harmane [1-methyl-9H-pyrido(3,4-b)indole] is a tremor-producing neurotoxin. Blood harmane concentrations are elevated in essential tremor (ET) patients for unclear reasons. Potential mechanisms include increased dietary harmane intake (especially through well-cooked meat) or genetic-metabolic factors. We tested the hypothesis that meat consumption and level of meat doneness are higher in ET cases than in controls. Methods: Detailed data were collected using the Lawrence Livermore National Laboratory Meat Questionnaire. Results: Total current meat consumption was greater in men with than without ET (135.3 ± 71.1 vs. 110.6 ± 80.4 g/day, p = 0.03) but not in women with versus without ET (80.6 ± 50.0 vs. 79.3 ± 51.0 g/day, p = 0.76). In an adjusted logistic regression analysis in males, higher total current meat consumption was associated with ET (OR = 1.006, p = 0.04, i.e., with 10 additional g/day of meat, odds of ET increased by 6%). Male cases had higher odds of being in the highest than lowest quartile of total current meat consumption (adjusted OR = 21.36, p = 0.001). Meat doneness level was similar in cases and controls. Conclusion: This study provides evidence of a dietary difference between male ET cases and male controls. The etiological ramifications of these results warrant additional investigation.

Copyright © 2008 S. Karger AG, Basel

 goto top of outline References
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 goto top of outline Author Contacts

Dr. Elan Louis
Unit 198, Neurological Institute
710 West 168th Street
New York, NY 10032 (USA)
Tel. +1 212 305 9194, Fax +1 212 305 1304, E-Mail edl2@columbia.edu

 goto top of outline Article Information

Received: September 26, 2007
Accepted: January 23, 2008
Published online: April 2, 2008
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 26

 goto top of outline Publication Details


Vol. 30, No. 3, Year 2008 (Cover Date: May 2008)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251–5350 (Print), eISSN: 1423–0208 (Online)

For additional information: http://www.karger.com/NED

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