Background/Aim: Harmane [1-methyl-9H-pyrido(3,4-b)indole] is a tremor-producing neurotoxin. Blood harmane concentrations are elevated in essential tremor (ET) patients for unclear reasons. Potential mechanisms include increased dietary harmane intake (especially through well-cooked meat) or genetic-metabolic factors. We tested the hypothesis that meat consumption and level of meat doneness are higher in ET cases than in controls. Methods: Detailed data were collected using the Lawrence Livermore National Laboratory Meat Questionnaire. Results: Total current meat consumption was greater in men with than without ET (135.3 ± 71.1 vs. 110.6 ± 80.4 g/day, p = 0.03) but not in women with versus without ET (80.6 ± 50.0 vs. 79.3 ± 51.0 g/day, p = 0.76). In an adjusted logistic regression analysis in males, higher total current meat consumption was associated with ET (OR = 1.006, p = 0.04, i.e., with 10 additional g/day of meat, odds of ET increased by 6%). Male cases had higher odds of being in the highest than lowest quartile of total current meat consumption (adjusted OR = 21.36, p = 0.001). Meat doneness level was similar in cases and controls. Conclusion: This study provides evidence of a dietary difference between male ET cases and male controls. The etiological ramifications of these results warrant additional investigation.
© 2008 S. Karger AG, Basel
- Dietary epidemiology, essential tremor
- Essential tremor
- Diet, tremor
- Metabolism, meat
- Benito-Leon J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA: Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord 2003;18:389–394.
- Dogu O, Sevim S, Camdeviren H, Sasmaz T, Bugdayci R, Aral M, Kaleagasi H, Un S, Louis ED: Prevalence of essential tremor: door-to-door neurological exams in Mersin Province, Turkey. Neurology 2003;61:1804–1806.
- Benito-Leon J, Bermejo-Pareja F, Louis ED: Incidence of essential tremor in three elderly populations of central Spain. Neurology 2005;64:1721–1725.
- Higgins JJ, Loveless JM, Jankovic J, Patel PI: Evidence that a gene for essential tremor maps to chromosome 2p in four families. Mov Disord 1998;13:972–977.
- Louis ED: Etiology of essential tremor: should we be searching for environmental causes? Mov Disord 2001;16:822–829.
- De Meester C: Genotoxic potential of beta-carbolines: a review. Mutat Res 1995;339:139–153.
- Anderson NJ, Tyacke RJ, Husbands SM, Nutt DJ, Hudson AL, Robinson ESJ: In vitro and ex vivo distribution of [3H]harmane, an endogenous β-carboline, in rat brain. Neuropharmacology 2006;50:269–276.
- Martin FC, Thu Le A, Handforth A: Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications. Mov Disord 2005;20:298–305.
- Handforth A, Krahl SE: Suppression of harmaline-induced tremor in rats by vagus nerve stimulation. Mov Disord 2001;16:84–88.
- O’Hearn E, Molliver ME: Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Neuroscience 1993;55:303–310.
- Louis ED, Zheng W, Jurewicz EC, Watner D, Chen J, Factor-Litvak P, Parides M: Elevation of blood β-carboline alkaloids in essential tremor. Neurology 2002;59:1940–1944.
- Louis ED, Zheng W, Applegate L, Shi L, Factor-Litvak P: Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology 2005;65:391–396.
- Louis ED, Applegate L, Graziano J, Parides M, Slavkovich V, Bhat H: Interaction between blood lead concentration and delta-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor. Mov Disord 2005;20:1170–1177.
- Keating GA, Bogen KT, Chan JM: Development of a meat frequency questionnaire for use in diet and cancer studies. J Am Diet Assoc 2007;107:1356–1362.
- Bogen KT, Keating GA 2nd, Chan JM, Paine LJ, Simms EL, Nelson DO, Holly EA: Highly elevated PSA and dietary PhIP intake in a prospective clinic-based study among African Americans. Prostate Cancer Prostatic Dis 2007;10:261–269.
- Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE: Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985;122:51–65.
- Louis ED, Ford B, Lee H, Andrews H: Does a screening questionnaire for essential tremor agree with the physician’s examination? Neurology 1998;50:1351–1357.
- Prakash KM, Fook-Choong S, Yuen Y, Tan EK: Exploring the relationship between caffeine intake and essential tremor. J Neurol Sci 2006;251:98–101.
- Louis ED, Jurewicz EC, Parides M: Case-control study of nutritional antioxidant intake in essential tremor. Neuroepidemiology 2005;24:203–208.
- Louis ED, Ford B, Frucht S: Factors associated with increased risk of head tremor in essential tremor: a community-based study in northern Manhattan. Mov Disord 2003;18:432–436.
- Louis ED, Dure L, Pullman S: Essential tremor in childhood. Mov Disord 2001;16:921–923.
- Tan EK, Lum SY, Prakash KM: Clinical features of childhood onset essential tremor. Eur J Neurol 2006;13:1302–1305.
- Mancini ML, Stracci F, Tambasco N, Sarchielli P, Rossi A, Calabresi P: Prevalence of essential tremor in the territory of Lake Trasimeno, Italy: results of a population-based study. Mov Disord 2007;22:540–545.
- Chen H, O’Reilly E, McCullough ML, Rodriguez C, Schwarzschild MA, Calle EE, Thun MJ, Ascherio A: Consumption of dairy products and risk of Parkinson’s disease. Am J Epidemiol 2007;165:998–1006.
- Byers TE, Rosenthal RI, Marshall JR, Rzepka TF, Cummings KM, Graham S: Dietary history from the distant past: a methodologic study. Nutr Cancer 1983;5:69–77.
- Thompson FE, Lamphiear DE, Metzner HL, Hawthorne VM, Oh MS: Reproducibility of reports of frequency of food use in the Tecumseh Diet Methodology Study. Am J Epidemiol 1987;125:658–671.
Dr. Elan Louis
Unit 198, Neurological Institute
710 West 168th Street
New York, NY 10032 (USA)
Tel. +1 212 305 9194, Fax +1 212 305 1304, E-Mail firstname.lastname@example.org
Received: September 26, 2007
Accepted: January 23, 2008
Published online: April 2, 2008
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 26
Vol. 30, No. 3, Year 2008 (Cover Date: May 2008)
Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251–5350 (Print), eISSN: 1423–0208 (Online)
For additional information: http://www.karger.com/NED
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