- Arsenic toxicity
- Matrix metalloproteinase
Objectives: To evaluate the efficacy of 2 potentized homeopathic remedies of Arsenicum Album (Ars Alb) – 6C and 30C – in combating chronic arsenic toxicity induced by repeated sublethal injections in mice (Mus musculus). Methods: Mice were randomized and divided into sets: (1) normal (control 1); (2) normal + succussed alcohol (control 2); (3) As2O3 (0.016%) injected at 1 ml/100 g body weight every 7 days (treated); (4) As2O3 injected + succussed alcohol (positive control); (5) As2O3 injected + Ars Alb 6C (drug-fed); (6) As2O3 injected + Ars Alb 30C (drug-fed). Cytogenetical endpoints like chromosome aberrations, micronuclei, mitotic index, sperm head abnormality and biochemical protocols like acid and alkaline phosphatases, aspartate and alanine aminotransferases, reduced glutathione, lipid peroxidation, catalase and succinate dehydrogenase were studied at 30, 60, 90 and 120 days. Results: Compared to controls, chromosome aberrations, micronuclei, sperm head abnormality frequencies and activities of acid and alkaline phosphatases, aspartate and alanine aminotransferases and lipid peroxidation were reduced in both drug-fed series, while mitotic index and activities of glutathione, catalase and succinate dehydrogenase were increased. Ars Alb 30C showed marginally better efficacy than Ars Alb 6C. Conclusion: Both remedies indicated potentials of use against arsenic intoxication.
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Anisur R. Khuda-Bukhsh
Department of Zoology, University of Kalyani
Kalyani, West Bengal 741235 (India)
Tel. +91 33 2582 8768, Fax +91 33 2582 8282, E-Mail firstname.lastname@example.org
Received: July 17, 2007
Accepted after revision: November 13, 2007
Published online: June 10, 2008
Number of Print Pages : 15
Number of Figures : 12, Number of Tables : 8, Number of References : 41
Pathobiology (Pathobiology - Exploring the basis of disease)
Vol. 75, No. 3, Year 2008 (Cover Date: June 2008)
Journal Editor: Borisch B. (Geneva), Yasui W. (Hiroshima)
ISSN: 1015–2008 (Print), eISSN: 1423–0291 (Online)
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