Cover

Sexual Dysfunction

The Brain-Body Connection

Editor(s): Balon R. (Detroit, Mich.) 
Table of Contents
Vol. 29, No. , 2008
Section title: Paper
Balon R (ed): Sexual Dysfunction. The Brain-Body Connection. Adv Psychosom Med. Basel, Karger, 2008, vol 29, pp 107-130
(DOI:10.1159/000126627)

Psychotropics and Sexual Dysfunction: The Evidence and Treatments

Labbate L.
Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Ark., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 4/8/2008
Cover Date: 2008

Number of Print Pages: 24
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8357-2 (Print)
eISBN: 978-3-8055-8358-9 (Online)

Abstract

Sexual dysfunction is common in the general population and even more common in the mentally or medically ill. Because mentally ill patients often receive psychotropics, many of which affect sexual functioning, a patient’s pre-existing sexual difficulties are often compounded, and these adverse effects may contribute to psychological difficulties or medication discontinuation. The effects of antidepressants, antipsychotics, mood stabilizers and anxiolytics on sexual functioning are critically reviewed. When possible, the types of sexual dysfunction (e.g. desire, arousal, or orgasm) induced by the drug is described. Treatments for drug-induced sexual function are described, but few controlled studies show benefit. Only sildenafil stands as a convincing treatment for drug-induced sexual dysfunction. The paper focuses on the placebo-controlled clinical trials that specifically evaluated sexual functioning in patients treated with psychotropics. Controlled studies are few for all the agents, though best for the antidepressants and antipsychotics. The exact magnitude and phase of sexual functioning affected remains to be elucidated for most psychotropic drugs. Although all phases of sexual functioning may be impaired by psychotropics, selective serotonin reuptake inhibitor antidepressants appear to primarily affect orgasm, while antipsychotics primarily affect desire. There is insufficient evidence to make conclusions about the anxiolytics or mood stabilizers.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 4/8/2008
Cover Date: 2008

Number of Print Pages: 24
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8357-2 (Print)
eISBN: 978-3-8055-8358-9 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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