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Vol. 30, No. 3, 2008
Issue release date: May 2008
Free Access
Neuroepidemiology 2008;30:191–204
(DOI:10.1159/000126911)

Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: The GENEVA Study

Rationale, Study Design and Demographic Characteristics

Schmidt S.a, b · Allen K.D.b, c · Loiacono V.T.a, b · Norman B.b, c · Stanwyck C.L.a, b · Nord K.M.a, b · Williams C.D.a, b · Kasarskis E.J.e · Kamel F.d · McGuire V.f · Nelson L.M.f · Oddone E.Z.b, c
aCenter for Human Genetics and bDepartment of Medicine, Duke University Medical Center, and cEpidemiology Research and Information Center, Durham VAMC, Durham, N.C., dEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, N.C., eLexington VAMC and University of Kentucky Medical Center, Lexington, Ky., and fStanford University School of Medicine, Stanford, Calif., USA
email Corresponding Author

Abstract

Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990–1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with the goal of enrolling all US veterans with a neurologist-confirmed diagnosis of ALS. The Genes and Environmental Exposures in Veterans with ALS study (GENEVA) is a case-control study presently enrolling cases from the Department of Veterans Affairs registry and a representative sample of veteran controls to evaluate the joint contributions of genetic susceptibility and environmental exposures to the risk of sporadic ALS. The GENEVA study design, recruitment strategies, methods of collecting DNA samples and environmental risk factor information are described here, along with a summary of demographic characteristics of the participants (537 cases, 292 controls) enrolled to date.


 goto top of outline Key Words

  • Amyotrophic lateral sclerosis, case-control study
  • GENEVA study recruitment methods
  • Gene-environment interaction

 goto top of outline Abstract

Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990–1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with the goal of enrolling all US veterans with a neurologist-confirmed diagnosis of ALS. The Genes and Environmental Exposures in Veterans with ALS study (GENEVA) is a case-control study presently enrolling cases from the Department of Veterans Affairs registry and a representative sample of veteran controls to evaluate the joint contributions of genetic susceptibility and environmental exposures to the risk of sporadic ALS. The GENEVA study design, recruitment strategies, methods of collecting DNA samples and environmental risk factor information are described here, along with a summary of demographic characteristics of the participants (537 cases, 292 controls) enrolled to date.

Copyright © 2008 S. Karger AG, Basel


 goto top of outline References
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 goto top of outline Author Contacts

Silke Schmidt, PhD
Center for Human Genetics, Department of Medicine
Duke University Medical Center, Box 3445
Durham, NC 27710 (USA)
Tel. +1 919 684 0624, Fax +1 919 684 0925, E-Mail silke.schmidt@duke.edu


 goto top of outline Article Information

Received: October 31, 2007
Accepted: January 31, 2008
Published online: April 18, 2008
Number of Print Pages : 14
Number of Figures : 3, Number of Tables : 3, Number of References : 94


 goto top of outline Publication Details

Neuroepidemiology

Vol. 30, No. 3, Year 2008 (Cover Date: May 2008)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251–5350 (Print), eISSN: 1423–0208 (Online)

For additional information: http://www.karger.com/NED


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990–1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with the goal of enrolling all US veterans with a neurologist-confirmed diagnosis of ALS. The Genes and Environmental Exposures in Veterans with ALS study (GENEVA) is a case-control study presently enrolling cases from the Department of Veterans Affairs registry and a representative sample of veteran controls to evaluate the joint contributions of genetic susceptibility and environmental exposures to the risk of sporadic ALS. The GENEVA study design, recruitment strategies, methods of collecting DNA samples and environmental risk factor information are described here, along with a summary of demographic characteristics of the participants (537 cases, 292 controls) enrolled to date.



 goto top of outline Author Contacts

Silke Schmidt, PhD
Center for Human Genetics, Department of Medicine
Duke University Medical Center, Box 3445
Durham, NC 27710 (USA)
Tel. +1 919 684 0624, Fax +1 919 684 0925, E-Mail silke.schmidt@duke.edu


 goto top of outline Article Information

Received: October 31, 2007
Accepted: January 31, 2008
Published online: April 18, 2008
Number of Print Pages : 14
Number of Figures : 3, Number of Tables : 3, Number of References : 94


 goto top of outline Publication Details

Neuroepidemiology

Vol. 30, No. 3, Year 2008 (Cover Date: May 2008)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251–5350 (Print), eISSN: 1423–0208 (Online)

For additional information: http://www.karger.com/NED


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

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